- Poster presentation
- Open Access
CMR trabecular fractal analysis - technical development of a measurement system
© Captur et al.; licensee BioMed Central Ltd. 2014
- Published: 16 January 2014
- Fractal Dimension
- Cardiovascular Magnetic Resonance
- Magnetic Field Strength
- Hypertrophic Cardiomyopathy
- Fractal Analysis
Cardiac trabeculae are complex and difficult to quantify but measuring their biological signal in many cardiac diseases (left ventricular [LV] non-compaction, hypertrophic cardiomyopathy [HCM]) has value. We have recently shown how trabeculae differ between ethnicities in health and between HCM mutation carriers without hypertrophy and healthy volunteers. Here we present a novel tool for measurement for LV trabecular complexity by cardiovascular magnetic resonance (CMR) using a fractal analysis. Theoretical fundamentals are discussed. They include the measurement procedure, mathematical modeling and performance evaluation through validation by digital phantoms and reproducibility analysis when applied to real-world cardiac data.
This is the first comprehensive implementation of a fractal procedure applied to the clinical CMR domain. Fractal analysis provides a way of collapsing the morphometric complexity of LV trabeculae into a single numerical value which can be compared between groups of subjects. Here we show how fractal analysis is a robust, reliable and reproducible method for capturing the richness of cardiac trabeculae imaged by CMR.
Dr Captur is funded by the University College London (Graduate Research Scholarship) and by the European Union (Science and Technology Research Grant). Dr Moon is funded by the Higher Education Funding Council for England.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.