- Poster presentation
- Open Access
Integrated treadmill stress testing and MR relaxometry (T1, T2, T2*): response in healthy calf muscles
© Varghese et al.; licensee BioMed Central Ltd. 2014
- Published: 16 January 2014
- Peripheral Arterial Disease
- Treadmill Exercise
- Calf Muscle
- Lateral Gastrocnemius
- Treadmill Stress
Peripheral arterial disease (PAD) is accompanied by a complex lower limb pathophysiology resulting in reduced functional capacity and quality of life. We aim to characterize the exercise recovery kinetics in the calf muscle of healthy volunteers by combining treadmill exercise and magnetic resonance (MR) relaxometry (T1, T2 and T2*), and to investigate their relation with age and treadmill exercise duration.
We investigated treadmill exercise induced changes in normal calf muscles, and showed the exercise induced response can be quantified by MR relaxometry, and is age and exercise duration dependent. In future patient studies, we will explore the integration of the clinical indices of disease severity (ABI-Ankle Brachial Index, Initial and Absolute Claudication Distance) with MR relaxometric measures to enhance our understanding of the pathophysiology and severity of PAD.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.