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What does valve, not myocardial LGE mean? Could it portend post-MI emergence of mitral regurgitation?

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Journal of Cardiovascular Magnetic Resonance201416 (Suppl 1) :P98

https://doi.org/10.1186/1532-429X-16-S1-P98

  • Published:

Keywords

  • Mitral Valve
  • Mitral Regurgitation
  • Late Gadolinium Enhancement
  • Valve Leaflet
  • Gadolinium Contrast

Background

Post-MI mitral regurgitation is thought to be due to passive, rather than active remodeling of mitral valve apparatus and relationship with other cardiac structures contributing to mitral regurgitation. Standard CMR late gadolinium enhancement (LGE) may be sensitive to non-myocardial pathology involving the mitral valve leaflets.

Methods

Presence or absence of MVE was noted in patients presenting for routine CMR with MI and non-MI indications requiring LGE. Chi square analysis was performed for non-contiguous variables and SPSS, Chicago software was utilized for statistical analysis. We hypothesize the presence of mitral valve enhancement (MVE) on LGE imaging in post-MI patients is associated with an increased incidence of MR.

Results

Patients (87; M = 54, F = 33) underwent LGE-CMR studies utilizing 1.5T GE (Milwaukee, WI) scanner with MultiHance (Bracco, Princeton, NJ) gadolinium contrast administration. LGE+ (present) in 68 and LGE- (absent) in 19 studies. Post-MI patterns of LGE+ in 51 and LGE- in 36 pts. MVE+ in 39, MVE- in 48. MR+ present in 67 and MR- in 20 studies. MVE was observed chiefly in post-MI patients (33 of 51; 65%) and infrequently in non-post-MI patients (6 of 36; 17%); χ2 = 17.8, p < 0.001, power = 0.995. Further, MR was present more frequently in patients with MVE (36 of 39; 92%) compared to patients without MVE (31 or 48; 65%); χ2 = 7.8, p = 0.005, power = 0.814 (see Figure 1).
Figure 1
Figure 1

Examples of MVE.

Conclusions

MVE is present in a large number of post-MI patients but rarely in non-post-MI patients. Post-MI patients with rather than without MVE are far more likely to have MR. These observations suggest a specific, as yet unknown, reactive process may contribute to mitral leaflet remodeling in post-MI patients potentially contributing to the increased incidence of MR in post-MI patients. Thus, active remodeling of the mitral valvar structure may be operative in conjunction with passive geometric LV remodling and collectively promote post-MI mitral regurgitation

Funding

Internal.

Authors’ Affiliations

(1)
Cardiac MRI, Allegheny General Hospital, Pittsburgh, Pennsylvania, USA

Copyright

© Bogabathina et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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