- Moderated poster presentation
- Open Access
Regional assessment of myocardial regeneration therapies in rats using magnetic resonance tagging
© Jackson et al; licensee BioMed Central Ltd. 2015
- Published: 3 February 2015
- Benzyl Alcohol
- Myocardial Regeneration
- Infarct Region
- Optical Projection
- Therapeutic Cell
The severely limited ability of the heart to repair itself following infarction has led to the development of a number of novel cell therapies aimed at stimulating myocardial regeneration. One promising technique is cellular monolayers consisting of fibroblasts and cardiomyocytes applied directly to the infarct region to promote regeneration. The study aims to assess the success of this patch treatment in rats using a combination of magnetic resonance imaging techniques to perform regional strain analysis and assess myofibre remodelling and use optical imaging techniques for tracking therapeutic cell retention.
This work is the first to combine advanced MRI tissue tagging and DTI with optical projection tomography to evaluate cardiac regenerative therapy. Initial data shows that treated hearts have reduced loss of contractility when compared to untreated infarctions. Myofibre remodelling in infarcted tissues is vital to functional recovery for infarcted hearts and DT-MRI can be used to monitor myofibre orientation and tissue anisotropy.
Medical Research Council, UK.
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