- Oral presentation
- Open Access
Heterogeneity of diffusion tensor imaging measurements of fractional anisotropy and mean diffusivity in normal human hearts in vivo
© McGill et al; licensee BioMed Central Ltd. 2015
- Published: 3 February 2015
- Cardiovascular Magnetic Resonance
- Fractional Anisotropy
- Diffusion Tensor Imaging
- Hypertrophic Cardiomyopathy
- Mean Diffusivity
Cardiac diffusion tensor imaging (cDTI) by cardiovascular magnetic resonance is becoming more robust for clinical imaging. It has the potential to assess microstructural changes, such as disarray in hypertrophic cardiomyopathy, through measures of fractional anisotropy (FA) and mean diffusivity (MD). However, normal variation in regional and transmural FA and MD is not well described.
Twenty normal subjects were imaged on a 3T Siemens Skyra scanner using a breath hold, mono-polar, diffusion weighted STEAM EPI sequence, as previously described. Imaging was performed in a short axis slice of the mid left ventricle, during the systolic pause, with an optimised protocol (bmain 750, bref 150 s/mm2).
FA and MD measurements are heterogeneous, varying significantly transmurally and regionally in the normal heart. Contributors to this heterogeneity are many, complex and interactive but may include SNR, variations in cardiac microstructure, partial volume effects and strain. These data indicate that the potential clinical use of FA and MD would require measurement standardisation by myocardial region and layer, unless pathological changes substantially exceed the normal variation identified.
The NIHR Cardiovascular Biomedical Research Unit at the Royal Brompton Hospital & Imperial College London.
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