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Cardiac mechanical activation mapping in heart failure patients with left bundle branch block using cine DENSE MRI
© Auger Cornejo et al; licensee BioMed Central Ltd. 2015
Published: 3 February 2015
Cardiac resynchronization therapy (CRT) is an effective treatment for selected patients with heart failure (HF) and left bundle branch block (LBBB). However, an ongoing major issue with CRT is that 30-50% of treated patients are non-responders. One potential cause of a poor response is implantation of the CRT left-ventricular (LV) pacing lead at a suboptimal location, i.e., a location with scar or where mechanical activation is not delayed [1, 2]. This study developed and applied cine DENSE strain imaging  to map mechanical activation and detect late-activated segments.
Cine DENSE strain imaging detects late-activated segments in HF patients with LBBB referred to CRT. Mechanical activation delays correlate with electrical activation times measured at matched locations. Heterogeneity in the location of late-activating segments suggests that activation mapping holds potential for pre-procedure identification of optimal LV lead implantation sites for individual patients undergoing CRT.
This research was funded in part by NIH R01 EB001763 and Siemens.
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