- Oral presentation
- Open Access
Elevated energy loss in diastolic left ventricular inflow corresponds to an increase in kinetic energy in patients with a repaired atrioventricular septal defect: Quantification from 4D Flow MRI
© ElBaz et al; licensee BioMed Central Ltd. 2015
- Published: 3 February 2015
- Kinetic Energy
- Energy Loss
- Average Kinetic Energy
- Atrioventricular Septal Defect
- Incompressible Newtonian Fluid
Patients after atrioventricular septal defect (AVSD) repair may present abnormalities in valve morphology and subsequently develop altered left ventricular (LV) inflow patterns . This may lead to energy loss and affect the kinetic energy in the LV. We aimed to quantify diastolic viscous energy loss and kinetic energy in the LV and to evaluate their association in AVSD-repaired patients compared to healthy controls using 4D Flow MRI.
Quantitative parameters of viscous energy loss and Kinetic energy during diastole in AVSD-repaired patients compared to controls
AVSD-repaired patients (N=23)
19 ± 8
20 ± 8
Heart rate (bpm)
87 ± 11
94 ± 15
0.21 ± 0.07
0.29 ± 0.12a
0.16 ± 0.07
1.31 ± 0.43
1.22 ± 0.5c
A significant increase in viscous energy loss (EL) is found in LV diastolic inflow of repaired-AVSD patients compared to healthy controls. This corresponded to higher levels of kinetic energy (KE) than controls. This parallel increase over diastole results in a ratio balance between EL and average KE comparable to controls. This could potentially be a mechanism of the heart to respond to the elevated levels of energy loss in the LV. This is one of the first in vivo studies to quantify and show the association between KE and EL from 4D Flow MRI. Further studies are needed to determine the impact of increased energy loss on cardiac function on the long term.
MSM ElBaz and J.J.M. Westenberg are financially supported by a grant from the Dutch Technology Foundation (STW) project number 11626.
E.E. Calkoen is financially supported by a grant from the Willem-Alexander Kinder- en Jeugdfonds, M.S.
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