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Blood flow pattern in the ascending aorta after TAVI and conventional aortic valve replacement: Analysis using 4D-Flow MRI
Journal of Cardiovascular Magnetic Resonance volume 17, Article number: O68 (2015)
Transarterial aortic valve implantation (TAVI) is a valid alternative to treat aortic stenosis in patients with high surgical risk. The impact of TAVI on changes in blood flow dynamics in the ascending aorta has not been systematically analyzed. Using temporally resolved, three-dimensional, phase contrast MRI (4D-flow), we studied 3D hemodynamics in the ascending aorta (AAo) after TAVI and compared the results to patients with conventional aortic valve replacement (AVR) as well as healthy controls.
We enrolled 17 subjects with TAVI (Edwards Sapien, mean age 77±7 years, 9 males), 12 with biological AVR (77±4 years, 8 males), and 9 healthy subjects (55±16 years, 8 males). All underwent 4D-flow MRI at 1.5T (spatial resolution 1.8 x 1.8 x 2.5mm3, temporal resolution 40.8ms). Analysis included quantification of the regional distribution of peak systolic wall shear stress (WSS) and peak systolic flow velocity in the AAo.
The mean aortic orifice area was 1.9±0.2cm2 (TAVI), 1.4±0.4cm2 (AVR) and 4.0 ±0.8cm2 (Controls) (p<0.001). Mean aortic diameter was 35±3mm, 39±4mm and 31±5mm (p=0.002). Patients with TAVI and AVR showed an asymmetric distribution of systolic WSS in the AAo compared to controls. WSS was significantly elevated anteriorly and right-anteriorly, and reduced posteriorly (Fig. 1). WSS distribution was similar in TAVI and AVR. Both TAVI and AVR exhibited the peak flow velocity along the right-anterior curvature, while this was more central in controls (Fig. 2). Peak velocities did not differ between TAVI and AVR (p=0.550).
TAVI and AVR lead to similar alterations in systolic blood flow patterns in the ascending aorta compared to healthy controls.
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Trauzeddel, R.F., Loebe, U., Barker, A.J. et al. Blood flow pattern in the ascending aorta after TAVI and conventional aortic valve replacement: Analysis using 4D-Flow MRI. J Cardiovasc Magn Reson 17, O68 (2015). https://doi.org/10.1186/1532-429X-17-S1-O68
- Wall Shear Stress
- Aortic Valve Replacement
- Aortic Diameter
- Orifice Area
- High Surgical Risk