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Non-contrast 3D radial and QISS MRA for transcatheter aortic valve replacement planning


Because of the high prevalence of renal insufficiency in patients eligible for transcatheter aortic valve replacement (TAVR), a non-contrast evaluation of the aortic root complex along with the entire vascular access route is desirable for pre-procedural evaluation. In this pilot study we proposed to test two novel investigational, non-contrast MRA techniques to develop a protocol for TAVR planning.


The study protocol was approved by the Institutional Review Board. Non-contrast MRA was performed in 7 subjects (5 healthy volunteers and 2 patients) on a 1.5T system (MAGNETOM Avanto, Siemens AG, Erlangen, Germany). A prototype 3D self-navigated whole-heart radial MRA acquisition based on a spiral phyllotaxis pattern was used to assess the cardiac anatomy and the aortic root (FOV 220mm3, TR/TE 3.1/1.5ms, flip angle 90°). This pulse sequence employs a superior-inferior bSSFP readout at the beginning of each heartbeat to correct the displacement in the k-space based on the blood pool signal. For the evaluation of the abdominal aorta and the femoral access route, both the 3D whole-heart (FOV 400mm3, TR/TE 3.1/1.5ms, flip angle 90°) and the prototype quiescent-interval single-shot (QISS) MRA pulse sequence were used (FOV 400x260mm2, TR/TE 3.5/1.4ms, flip angle 90°, acquisition length 144mm, number of stations 3-4). Aortic root, abdominal aorta and femoral runoff measurements were obtained and image quality was evaluated. Aortic root parameters were compared to measurements obtained by conventional cine acquisition, and abdominal aorta and femoral measurements were correlated between the 3D and QISS MRA acquisitions.


Representative thoracic and abdominal images obtained by the 3D whole heart sequence, as well as abominal MIP acquired by the QISS sequence are shown in Figure 1. The acquisition time of the thoracic 3D whole-heart scan, the abdominal 3D scan, and the abdominal QISS acquisition was 6.4±1.2, 6.3±1.1, and 3.1±0.5min, respectively. The minimum and maximum diameter, the perimeter, and the area of the aortic root were not different between the 3D whole-heart and the 2D bSSFP cine acquisitions (Table 1). No significant difference was found in the diameter of the abdominal aorta or the iliac and femoral arteries between the 3D and the QISS acquisitions (Table 1). The 3D whole heart acquisition provided a significantly better contrast-to-noise ratio (CNR) compared to the 2D bSSFP cine, however, CNR was not significantly different between images obtained by the 3D and QISS MRA protocols (Table 1).

figure 1

Figure 1

Table 1 Aortic root, abdominal and femoral vascular assessment


These preliminary results suggest that the 3D whole-heart acquisition technique provides rapid, free-breathing assessment of the cardiac and aortic root anatomy without the administration of contrast medium. Although the 3D whole-heart acquisition also enables the assessment of the abdominal vascular status, the QISS MRA provides significantly faster evaluation of the femoral access route, which improves patient compliance.



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Varga-Szemes, A., Cannao, P.M., Muscogiuri, G. et al. Non-contrast 3D radial and QISS MRA for transcatheter aortic valve replacement planning. J Cardiovasc Magn Reson 17 (Suppl 1), O71 (2015).

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