Skip to main content
  • Poster presentation
  • Open access
  • Published:

Fully-automatic synthesis of cine viability CMR images with minimal estimation error


A typical CMR exam includes cine, tagging, and delayed-hyperenhancement (DHE) sequences to produce images for evaluating global heart function, myocardial contractility, and viability, respectively. Usually, DHE imaging is conducted at mid-diastole. Nevertheless, obtaining cine DHE images is appealing to obtain simultaneous information about tissue viability and wall motion abnormality. In this study, we compare the performance of four image analysis techniques for generating the cine DHE images based on estimating tissue motion, validate the results on numerical phantom, and implement on in-vivo images.


A numerical phantom of a grid-tagged short-axis slice, that experiences cyclic deformation, was built to test the performance of four techniques for estimating the motion field used to generate the cine DHE images: harmonic phase (HARP)[1], and three optical-flow (OF) methods[24]: Lucas-Kanade optical-flow (LKOF), Horn-Shunck (HSOF), and band-pass (BPOF). The generated motion fields are compared to the ground-truth motion.

Cine, DHE, and tagged images were acquired from four patients with myocardial infarction (MI) on 3T scanner. The motion field was estimated from the tagged images and used to reconstruct cine DHE images starting from the acquired (known) DHE image. Wall thickening was measured from both cine and generated DHE images. MI was determined using full-width at half-maximum method. Circumferential strain was measured from the tagged images using Diagnosoft software.


BPOF resulted in minimal tracking error compared to other techniques. The tracking accuracy of BPOF was close to HARP for intramyocardial points; however, it was significantly higher at the boundaries, where HARP failed to track the tag points. Fig.1(a,b) shows the tagging grid at end-diastole (initial frame) and tracking results at end-systole using HARP and BPOF. Fig.1(c-e) shows the average tracking error for points on the epicardium, endocardium, and mid-myocardium.

Figure 1
figure 1

Phantom results. Grid-tagged images at (a) end-diastole and (b) end-systole, showing tracking results from BPOF (green) and HARP (red). Tracking error at (c) epicardium, (d) mid-myocardium, and (e) endocardium using HARP (red), LKOF (blue), HSOF (brown), and BPOF (green). BPOF shows lowest error amoung all methods, and outperforms HARP at the boundaries.

2 shows cine images, and corresponding synthesized DHE images (using BPOF), of the same slices at end-systole and end-diastole. The results showed strong correlation between wall thickening measured from both datasets (R>0.7). Further, myocardial strain showed strong inverse correlation (|R|>0.8) with MI transmurality measured from the synthesized DHE images.

Figure 2
figure 2

Cine images at (a) end-diastole and (b) end-systole with (c,d) corresponding synthetic DHE images. (e) and (f) show the DHe regions and wall thickness in corresponding synthetic DHE images.


BPOF has minimal error in tracking taglines and measuring motion field, which can be used for generating cine DHE images. The generated cine DHE images may be important for comprehensive evaluation of the patient's condition, as they show simultaneous myocardial viability and wall motion abnormality on the same dataset without additional scan time or misregistration problems.




  1. IEEE-TMI. 19 (3): 186-202.

  2. Intl J Comput-Vis. 1111, 12: 43-77.

  3. Artif Intel. 1111, 17: 185-204.

  4. Med Physic. 1111, 27 (1): 108-118.

Download references

Author information

Authors and Affiliations


Rights and permissions

Open Access  This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made.

The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.

To view a copy of this licence, visit

The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Hassanein, A.S., Khalifa, A.M. & Ibrahim, ES. Fully-automatic synthesis of cine viability CMR images with minimal estimation error. J Cardiovasc Magn Reson 17 (Suppl 1), P106 (2015).

Download citation

  • Published:

  • DOI: