Head-to-head comparison of myocardial perfusion SPECT and CMR for assessment of myocardial ischemia
© Hedeer et al; licensee BioMed Central Ltd. 2015
Published: 3 February 2015
Myocardial perfusion single photon emission computed tomography (MPS) and cardiac magnetic resonance (CMR) can be used for assessment of myocardial ischemia. The methods reveal different aspects of the pathophysiology associated with myocardial ischemia where MPS is based on uptake of a perfusion tracer in viable mitochondria whereas CMR is based on first-pass perfusion reflecting coronary in-flow kinetics. The aim of this study was to perform a head-to-head comparison between MPS and CMR for assessment of myocardial ischemia under identical perfusion conditions at stress.
Ninety-six patients (34 females) were included in the study. All patients completed both gated MPS and CMR at rest and during adenosine stress. The MPS and CMR perfusion tracers were injected in the MR scanner during the same adenosine stress session. MPS images were acquired approximately one hour after the first-pass perfusion images. Qualitative image analysis for stress-induced ischemia was performed by two expert readers blinded to all clinical data.
Number of patients with myocardial ischemia for MPS and CMR respectively.
When assessing myocardial ischemia in patients under identical myocardial perfusion conditions at stress there are disagreements between MPS and CMR in a significant number of cases. The prognostic significance of these findings remains to be determined.
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