- Poster presentation
- Open Access
Diabetes mellitus is an independent predictor of right ventricular dysfunction
© Roifman et al; licensee BioMed Central Ltd. 2015
- Published: 3 February 2015
- Diabetes Mellitus
- Percutaneous Coronary Intervention
- Right Ventricular
- Ventricular Dysfunction
- Primary Percutaneous Coronary Intervention
The World Health Organization estimates that diabetes mellitus (DM) affects 347 million people worldwide and will be the 7th leading cause of death by 2030. Right ventricular (RV) myocardial infarction and subsequent dysfunction complicating STEMI is independently associated with a higher mortality. Emerging research suggests that mechanisms for RV dysfunction may be different than those governing left ventricular dysfunction. The relationship between DM and RV dysfunction is currently unknown. The primary purpose of this study was to determine whether DM is an independent predictor for the development of right ventricular dysfunction.
106 patients post primary percutaneous coronary intervention for STEMI were enrolled in this study between the years 2009-2013. Each patient had a cardiac MRI done on a on a 1.5T scanner within 48-72 hours of admission. Cardiac function was determined using contiguous short axis slices covering the left and right ventricle acquired with a standard SSFP sequence. RV dysfunction was defined as an MRI derived RVEF <50%. Univariate analyses were performed using the chi square, fisher's exact test, t-test, or Wilcoxon rank sum test as appropriate. Subsequently, multivariable logistic regression analysis was done in order to determine if the presence of DM was independently predictive of RV dysfunction. Predictor variables with a p value <0.25 in the univariate analysis were included in the multivariable model.
Univariate analyses assessing the relationship between predictor variables and RVMI
No RVMI (n=59)
Age in years (median, IQR)
58 (52, 68)
58 (53, 66)
Previous MI (%)
Serum Creatinine in umol/l (median, IQR)
78 (66.50, 88.50)
78 (67, 95)
Peak creatine kinase in standard units/l (median, IQR)
1666.50 (815, 2395)
2096 (1103, 2964)
Multivariable logistic regression analysis assessing the relationship between predictor variables and RVMI
Odds Ratio (95%CI)
Omnibus Likelihood Ratio (x2 (df))
Prior MI (yes vs. no)
4.67 (0.46, 47.03)
Peak CK in standard units/l
1.0 (0.99, 1.0)
Diabetes (yes vs. no)
2.78 (1.12, 6.87)
The presence of DM is an independent predictor for the development of RV dysfunction post STEMI. In fact, its presence was associated with an approximately 3 fold greater odds of developing RV dysfunction. No other major cardiovascular risk factors were independently associated with the development of RV dysfunction in our cohort.
Research support for this project was provided by GE healthcare and the Ontario Research Fund.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.