- Poster presentation
- Open Access
Prediction of appropriate ICD-therapy using infarct heterogeneity from CMR in patients with coronary artery disease
© Jablonowski et al; licensee BioMed Central Ltd. 2015
- Published: 3 February 2015
- Cardiac Magnetic Resonance
- Late Gadolinium Enhancement
- Cardiac Magnetic Resonance Imaging
- Improve Patient Selection
- Threshold Algorithm
The heterogeneous peri-infarction zone surrounding the core infarct with cardiac magnetic resonance imaging (CMR) late gadolinium enhancement (LGE) has been linked to all-cause mortality in patients with coronary artery disease. Previously, the heterogeneity of fibrotic areas has been analyzed by threshold algorithms. We hypothesized that the heterogeneous peri-infarction zone is related to appropriate ICD-therapy in ischemic cardiomyopathy patients. Therefore, the purpose of this study was to investigate if 1) infarct heterogeneity can predict appropriate ICD-therapy and 2) evaluate which analysis method best depicts and quantifies the peri-infarction zone.
A total of 14 patients were included in the analysis, six patients with appropriate ICD-therapy (age 53±11years, 100% male, LV-EF 29±9%) and eight patients with no ICD-therapy (age 55±14years, 100% male, LV-EF 26±4%). The total scar burden was similar between both groups with and without ICD-therapy (49±13g vs 45±8g, p=0.1).
The peri-infarction zone quantified on CMR using a semi-automatic algorithm was larger in patients with appropriate ICD-therapy compared to patients with no ICD-therapy. The use of a threshold algorithm did, however, not separate the groups. Accurate quantification and characterization of the peri-infarction zone could aid in the identification of patients with infarction and at risk of ventricular arrhythmias and help to improve patient selection for primary prevention with ICD-therapy.
Lund University, Region of Scania.
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