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Prediction of appropriate ICD-therapy using infarct heterogeneity from CMR in patients with coronary artery disease
Journal of Cardiovascular Magnetic Resonance volume 17, Article number: P165 (2015)
The heterogeneous peri-infarction zone surrounding the core infarct with cardiac magnetic resonance imaging (CMR) late gadolinium enhancement (LGE) has been linked to all-cause mortality in patients with coronary artery disease. Previously, the heterogeneity of fibrotic areas has been analyzed by threshold algorithms. We hypothesized that the heterogeneous peri-infarction zone is related to appropriate ICD-therapy in ischemic cardiomyopathy patients. Therefore, the purpose of this study was to investigate if 1) infarct heterogeneity can predict appropriate ICD-therapy and 2) evaluate which analysis method best depicts and quantifies the peri-infarction zone.
Ischemic cardiomyopathy patients with a primary prophylactic ICD who underwent CMR on a 1.5T scanner prior to ICD implantation were retrospectively included and divided into two groups (i) patients with appropriate ICD-therapy (anti-tachy pacing, shock or both) and (ii) patients with no ICD-therapy. A newly developed semi-automatic quantitative algorithm was used to evaluate the peri-infarction zone. This method was compared against a previously used threshold method with the total scar area defined as signal intensity (SI)>2SD from remote myocardium, infarct core as SI>3SD from remote and the peri-infarction zone defined as SI between 2 and 3SD from remote (Figure 1). Differences with a p<0.05 were considered statistically significant.
A total of 14 patients were included in the analysis, six patients with appropriate ICD-therapy (age 53±11years, 100% male, LV-EF 29±9%) and eight patients with no ICD-therapy (age 55±14years, 100% male, LV-EF 26±4%). The total scar burden was similar between both groups with and without ICD-therapy (49±13g vs 45±8g, p=0.1).
The mean peri-infarction zone normalized to the total scar using the semi-quantitative algorithm was larger in the group with appropriate therapy (34±1%) compared to the group with no ICD-therapy (30±1%, p=0.03), Figure 2. There was no difference between groups using the threshold algorithm for peri-infarction zone analysis (11±2% with appropriate ICD-therapy vs 10±2% with no therapy, p=0.4). There was a significant difference in peri-infarction zone normalized for total scar between the semi-automatic and threshold algorithm for patients with appropriate therapy (p=0.002) and no therapy (p=0.0003).
The peri-infarction zone quantified on CMR using a semi-automatic algorithm was larger in patients with appropriate ICD-therapy compared to patients with no ICD-therapy. The use of a threshold algorithm did, however, not separate the groups. Accurate quantification and characterization of the peri-infarction zone could aid in the identification of patients with infarction and at risk of ventricular arrhythmias and help to improve patient selection for primary prevention with ICD-therapy.
Lund University, Region of Scania.
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Jablonowski, R., Chaudhry, U., Engblom, H. et al. Prediction of appropriate ICD-therapy using infarct heterogeneity from CMR in patients with coronary artery disease. J Cardiovasc Magn Reson 17, P165 (2015). https://doi.org/10.1186/1532-429X-17-S1-P165
- Cardiac Magnetic Resonance
- Late Gadolinium Enhancement
- Cardiac Magnetic Resonance Imaging
- Improve Patient Selection
- Threshold Algorithm