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Assessing right ventricular function in patients with pulmonary hypertension based on noninvasive measurements: correlation between cardiac MRI, ultrasonic cardiogram, multidetector CT and right heart catheterization

Background

The assessment of right ventricular function is of great importance in the management of patients with pulmonary hypertension (PH). Our aim is to compare the value of cardiac MRI (CMRI), ultrasonic cardiogram (CUS), multidetector CT (MDCT) in assessing right ventricular function, and to evaluate the correlation between parameters derived by MRI, CUS, MDCT and the indicators of right ventricular function derived by right heart catheterization (RHC) in patients with PH.

Methods

Thirty one consecutive patients with PH (17 males and 14 females; mean age, 54.61±11.74 years; range, 33 to 76 years) were prospectively enrolled.All patients underwent RCH to get hemodynamic parameters .Then, calculations including pulmonary vascular resistance index (PVRI), right cardiac work index (RCWI), right ventricular stroke work index (RVSWI) were performed. All patients underwent CMRI to get parameters including right ventricular end-systolic volume (ESV), end-diastolic dimension (EDV), stroke volume (SV), ejection fraction (EF), the cardiac muscle mass (CMS). 28 patients underwent CUS to get these parameters including right ventricular Tei index, right ventricular fractional area change (RV FAC), RV-ESV, RV-EDV. And 25 patients underwent MDCT to get these parameters including right /left ventricular internal diameter (RVd/LVd), right /left ventricular diastole maximum area (RVa/LVa), cobb angle, right ventricular free wall thickness (RVWT). All examinations were executed within 7days. These parameters obtained by MRI, CUS and MDCT were correlated with those of RCH respectively by Spearman or Pearson correlation analysis.

Results

Most parameters of RV function derived by CMRI, CUS, MDCT correlated moderately with mPAP, PVRI. mPAP had strong correlation with MRI-ventricular mass index (VMI)(r=0.528, P=0.002), RVWT (r=0.554, P=0.005); PVRI had strong correlation with MRI-EF(r=-0.647, P=0.000), MRI-VMI(r=-0.567, P=0.001), CT-RVd(r=0.536, P=0.006), RVd/LVd (r=0.530, P=0.006), CT-Cobb angle(r=0.608, P=0.001), RVWT(r=0.586, P=0.003). Table 1 showed the correlation of right ventricular function between CMRI, CUS, MDCT and RHC. RHC-SV had the strong correlation with MRI-EF(r=0.557, P=0.001), CT-RVd(r=-0.502, P=0.011), CT-Cobb angle(r=-0.503, P=0.003).

Table 1 Correlation coefficients of right ventricular function parameters between CMRI, CUS,M DCT and RHC.

Conclusions

The parameters obtained by MRI, CUS and MDCT had moderate correlation with RHC-SV. MRI-EF was the best parameter to reflect RV function which could be used to exactly evaluate RV function in patient with PH. Among these noninvasive measurements, CMRI is the optimal method to assess RV function, and then is the MDCT and the last is CUS.

Funding

the National 12th Five-Year Researching Foundation (2011BAI11B17).

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Correspondence to Xiaojuan Guo.

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Guo, X., Liu, M., Ma, Z. et al. Assessing right ventricular function in patients with pulmonary hypertension based on noninvasive measurements: correlation between cardiac MRI, ultrasonic cardiogram, multidetector CT and right heart catheterization. J Cardiovasc Magn Reson 17, P185 (2015). https://doi.org/10.1186/1532-429X-17-S1-P185

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Keywords

  • Pulmonary Hypertension
  • Right Heart Catheterization
  • Stroke Work Index
  • Fractional Area Change
  • Pulmonary Vascular Resistance Index