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Prevalence of cardiovascular abnormalities in obese adults referred for bariatric weight loss surgery

Background

Obesity is associated with increased risk of death that may be related to underlying structural and functional changes in the heart. Cardiac MR (CMR) can provide detailed structural and functional information about the heart and vasculature that may improve our understanding of obesity related cardiac morbidity and mortality.

Methods

A cohort of 77 obese patients referred for stress CMR for evaluation of dyspnea prior to weight-loss surgery (WLS) were identified from our research registry. All patients underwent standard vasodilator stress perfusion protocol with late gadolinium enhancement (LGE) imaging on a 1.5T MR system. We collected demographic and CMR data including ventricular volumes, global and regional functional indices, and results of stress and LGE imaging. Comparison of CMR was made to previously derived and universally accepted normative data. The goal will be to assess these parameters 1 year post WLS and analyze the structural, functional and microvascular changes.

Results

Please see table 1.

Table 1 Summary data of LV and RV indices compared to normative derived data* (mean ± SD, 95% confidence interval)

Conclusions

Multiple cardiovascular abnormalities are noted in severely obese patients including LV and RV dilation and microvascular ischemia that may contribute to the increased cardiovascular morbidity and mortality observed in this population.

Funding

Empire Clinical Research Investigator Program (ECRIP).

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Correspondence to Tendoh Timoh.

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Timoh, T., Dalal, R., Ali, S. et al. Prevalence of cardiovascular abnormalities in obese adults referred for bariatric weight loss surgery. J Cardiovasc Magn Reson 17, P188 (2015). https://doi.org/10.1186/1532-429X-17-S1-P188

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Keywords

  • Late Gadolinium Enhancement
  • Stress Perfusion
  • Vasodilator Stress
  • Late Gadolinium Enhancement Imaging
  • Cardiovascular Abnormality