Volume 17 Supplement 1
Correlation of electrocardiographic conduction abnormalities with myocardial fibrosis and scar in late enhancement
© Grebe et al; licensee BioMed Central Ltd. 2015
Published: 3 February 2015
Late Gadolinium enhancement represents a widely employed method for detecting myocardial scarring e.g. after myocardial infarction or for myocardial Inflammation. A frequent finding is slight basal septal enhancement as well as intramyocardial enhancement, mostly referred as myocardial fibrosis. Less is known about the impact on myocardial conduction and a possible correlation to ECG findings such as atrioventricular node conduction delay and bundle branch blockations.
For 81 consecutive patients (mean age 63,5yrs, range 20-84yrs, 17 female) referred for magnetic resonance cardiac (MRI) including a late gadolinium enhancement study scans were anonymized and correlated to an ECG performed within one week before or after the MRI. A 1.5T Siemens Sonata with TIM upgrade was used. Scanning protocol comprised short- and long axis cine mode and a perfusion study with Gd-DOTA and/or T1 and T2 TSE as well as 2d and 3d IR short axis sequences for late enhancement. The latter was analysed visually for the study by two experienced operators and subdived as (1) normal, (2) intramyocardial fibrosis, (3) subendocardial or transmural ischemic scar and (4) bright acute inflammation or postmyocardial subepicardial enhancement pattern. The ECGs had been re-evaluated by an experienced cardiologist.
The baseline data between the 4 groups was similar (data given as mean values and range):
group 1 (normal): 30 patients (37%), LVEF 62% (17-79%), EDVI 73ml (40-222ml), ventricular septum thickness (IVS) 11mm, age 57yrs;
group 2 (fibrosis): 30 patients (37%), LVEF 58% (20-76%), EDVI 72ml (45-142ml), IVS 13mm, age 68yrs;
group 3 (ischemic scar): 15 patients (19%), LVEF 51% (30-76%), EDVI 82ml (36-152ml), IVS 11mm, age 69yrs;
group 4 (myocarditis): 6 patients (7%), LVEF 55% (42-71%), EDVI 82ml (57-122ml), IVS 10mm, age 44yrs.
Atrial fibrillation was present in 10%, 20%, 27%, and 0% respectively.
Abnormal ECG findings such as AV conduction delay and bundle branch blockation are significantly correlated to myocardial scarring or fibrosis in late enhancment studies.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.