- Poster presentation
- Open Access
The utility of free-breathing, motion-corrected late gadolinium enhancement for right ventricular fibrosis imaging in congenital heart disease
© Heng et al; licensee BioMed Central Ltd. 2015
- Published: 3 February 2015
- Cardiovascular Magnetic Resonance
- Image Quality Score
- Adult Congenital Heart Disease
- Balance Steady State Free Precession
- Adult Congenital Heart Disease Patient
Ventricular fibrosis in adult congenital heart disease (ACHD) has been shown to relate to adverse clinical markers.[1, 2] Novel free-breathing, motion-corrected late gadolinium enhancement cardiovascular magnetic resonance (LGE CMR) has been shown to be advantageous in quantifying LV LGE, but has not been evaluated for RV LGE.  It may therefore also be beneficial in ACHD patients, particularly with RV LGE patterns. We sought to investigate its clinical utility in ACHD patients undergoing LGE CMR.
Ten adult repaired Tetralogy of Fallot patients aged ≥16 years with glomerular filtration rate>30ml/min completed clinical CMR scans acquired by a single operator on a 1.5T Siemens Avanto for volumetric and functional biventricular assessment. LGE imaging was performed 10 minutes after 0.1mmol/kg intravenous gadobutrol administration (Bayer, Germany).
Interspersed breath-hold (BH) segmented gradient echo and free-breathing (FB) motion-corrected balanced steady state free precession phase-sensitive inversion recovery (PSIR) pulse sequences were acquired with identical typical imaging parameters of: field of view 380x320mm, matrix 256x144, 6mm slice thickness with 4mm gap for short-axis stacks, and acceleration factor (GRAPPA) 2. Repetition time/echo time of 8.3/3.8ms (BH) 2.7/1.7ms (FB), flip angle 25o (BH) and 50o (FB), pixel bandwidth 140Hz (BH) 977Hz (FB) with acquisition window 166ms (BH) 196ms (FB) were set. Inversion times were adjusted for myocardial nulling throughout, and kept constant between both sequences when acquiring identical slice locations in long and short-axis views. When inversion time drift was minimal, transverse navigator-gated 3D LGE imaging was performed as per published protocol as a reference standard.4
Anonymised, blinded image analysis was carried out by two experienced observers assessing RV LGE image quality,5 image confidence scores and semi-quantitative RV LGE scoring.1Blood-myocardium and Gd-myocardium contrast-to-noise ratios (CNRs) were also compared.
Free-breathing LGE provides comparable, diagnostic image quality to conventional 2D BH LGE imaging and may be practical for clinical use, especially for patients unable to breath-hold or with arrhythmias that would otherwise compromise image quality.
British Heart Foundation, NIHR Cardiovascular Biomedical Research Unit of Royal Brompton & Harefield NHS Foundation Trust and Imperial College London.
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