Realtime MR guided endomyocardial biopsy with an active visualization bioptome
© Rogers et al; licensee BioMed Central Ltd. 2015
Published: 3 February 2015
Invasive endomyocardial biopsy is an important tool to diagnose cardiomyopathy. But the diagnostic yield is low because the procedure is performed ‘blind' using, particularly in processes characterized by heterogeneous myocardial involvement. MRI tissue characterization techniques, using late gadolinium enhancement or T1 mapping for example, can identify affected regions and guide biopsy. We performed realtime MR guided transcatheter endomyocardial biopsy using a novel active visualization MR conditional bioptome in swine.
An active visualization MR conditional bioptome was designed and built for transcatheter endomyocardial biopsy. All materials were chosen to minimize MR imaging artifacts and to minimize device heating during use in the MR environment. Active visualization of the bioptome shaft was achieved by embedding a loopless dipole RF antenna. The bioptome was tested in a phantom and in vivo in swine to perform transcatheter right and left ventricular endomyocardial biopsy under realtime MR guidance.
We have developed and tested in vivo an active visualization MR conditional endomyocardial bioptome. We have demonstrated clear visualization of the bioptome shaft and jaws under realtime MR guidance. In an animal experiment, the bioptome was steered to different locations with the ventricles and multiple biopsy samples were obtained.
This work was supported by the Division of Intramural Research, National Heart Lung and Blood Institute, National Institutes of Health (Z01-HL005062) and by a SBIR contract to MRI Interventions.
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