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  • Open Access

Left ventricular and atrial function in systemic light chains amyloidosis: an echocardiography and cardiac magnetic resonance comparison

  • 1,
  • 1,
  • 2,
  • 1,
  • 2,
  • 1 and
  • 3
Journal of Cardiovascular Magnetic Resonance201517 (Suppl 1) :P369

https://doi.org/10.1186/1532-429X-17-S1-P369

  • Published:

Keywords

  • Amyloidosis
  • Cardiac Magnetic Resonance
  • Late Enhancement Gadolinium
  • Left Atrial
  • Left Atrial Volume

Background

Cardiac involvement in systemic light-chain amyloidosis (AL) is characterized by slightly decreased systolic left ventricular function (LV) function and typically a diastolic dysfunction including left atrial (LA) enlargement. Cardiac magnetic resonance (CMR) is often performed in AL to accurately assess chambers size and function. We aimed to compare features of LV systolic and diastolic function obtained by 2D transthoracic echocardiography (TTE), with morphological and functional myocardial LV (presence of late gadolinium enhancement: LGE) and LA (volume and emptying fraction) parameters as assessed by CMR in a consecutive series of patients with cardiac AL.

Methods

Thirty-five consecutive patients in sinus rhythm (66±10 years, 59% males) with confirmed systemic AL, underwent TTE and CMR within the same day. LVEF and LV 2D global longitudinal speckle tracking imaging obtained by TTE were stratified according to the presence or not by CMR, of myocardial late enhancement gadolinium (LV-LGE). Left atrial emptying fraction (LAEF) was calculated after assessing the maximal and minimal LA volume (by area/length formula) in CMR using 4 and 2 chambers views and the following formula: Max LAV-Min LAV/ Max LAV

Results

2D- LVEF and global longitudinal speckle tracking imaging were significantly decreased in patients with LV-LGE when compared to those without: 56.5±10.4% vs. 63.5±10.2%, p=0.04 and -10.8±2.8% vs. -16.6±5.02%, p=0.0005 respectively. Diastolic mitral deceleration time and E/A ratio and E/e' at lateral annulus were significantly altered in patients with low LA-EF < 24% median value) vs. those with higher LA-EF whereas, they were not significantly different according to max-LAV by CMR (Figure 1)

Figure 1

Conclusions

In systemic AL, reduced systolic LV 2D speckle tracking imaging is significantly associated with the presence of LV-LGE while impaired LV filling pressures are rather related to decreased in LA emptying fraction. Multimodality imaging in patients with AL may allow complementary and better assessment of LV hemodynamics. However, larger series are needed to confirm these results.

Funding

None.

Authors’ Affiliations

(1)
Cardiology, CHU Limoges, Limoges, France
(2)
Cardiology, CHU Henri Mondor, Créteil, France
(3)
Hematology, CHU Limoges, Limoges, France

Copyright

© Mohty et al; licensee BioMed Central Ltd. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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