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- Open Access
Decreased coronary artery distensibility measured using 3T MRI is related to systemic inflammation in patients with coronary artery disease
© Petrose et al; licensee BioMed Central Ltd. 2015
- Published: 3 February 2015
- Coronary Artery Disease
- Adiponectin Level
- Coronary Artery Disease Patient
- Lumen Area
- hSCRP Level
We previously reported that coronary distensibility can be measured non-invasively using 3T MRI and that distensibility is reduced in coronary artery disease (CAD) patients compared with healthy subjects. Because atherosclerotic vascular disease is an inflammatory process, we sought to test the hypothesis that coronary distensibility measured with MRI is associated with systemic inflammation, measured by serum high sensitivity C reactive protein, hsCRP, a marker of increased inflammation, and adiponectin, a fat hormone associated with decreased inflammation, in healthy subjects and in CAD patients.
25 subjects (8 healthy adults, age=38.6±6.5years,mean±standard error) and 17 patients with catheterization-documented CAD (age=59.4±3.4) were studied using a commercial whole-body MR imaging system (Achieva 3.0T;Philips,Best,Netherlands). Spiral cine MRI was performed for area measurements of a proximal coronary artery. MRI parameters were:echo time (TE)=1.5ms,radiofrequency(RF) excitation angle=20°;spectral spatial excitation,acq. window=10ms,repetition time(TR)=14ms,21 spiral interleaves,spatial resolution(acquired/reconstructed)=0.89x0.89x8.00mm3/0.69x0.69x8.00mm3. Blood pressure and heart rate were recorded. Images were analyzed for cross-sectional area in systole and diastole using semi-automated software (Cine vs3.15.17,General Electric), and distensibility(mmHg-1) was determined as: [(systolic lumen area-diastolic lumen area)]/(pulse pressure multiplied by diastolic lumen area). Blood was obtained the same day as the MRI to quantify serum hsCRP and adiponectin (in a subset,n=16).
Coronary distensibility measured noninvasively by 3T MRI is impaired in CAD patients compared to healthy controls and the degree of distensibility in CAD patients is inversely related to hSCRP level, a marker of inflammation. Adiponectin, a fat hormone known to suppress inflammation, is positively related to distensibility. These data suggest that systemic inflammation is closely related to coronary distensibility. Further studies are needed to determine whether suppressing inflammation improves coronary distensibility and other measures of vascular disease.
NIH/NHLBI grants R01HL084186, AHA SDG 5200004, AHA 12PRE11510006.
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