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Co-registered MR tissue phase mapping and speckle tracking echocardiography: inter-modality comparison of regional myocardial velocities in pediatric patients
© Camarda et al; licensee BioMed Central Ltd. 2015
- Published: 3 February 2015
- Speckle Tracking Echocardiography
- Regional Velocity
- Tissue Phase Mapping
- Short Axis Orientation
- Single Cardiac Cycle
MR tissue phase mapping (TPM) enables assessment of regional myocardial velocities. The purpose of this study was to compare regional myocardial velocities obtained by both TPM and speckle tracking echocardiography (STE) to assess agreement and potential systematic differences between modalities.
N=19 patients with congenital heart abnormalities and biventricular physiology who had undergone cardiac MRI including TPM and transthoracic echocardiography within 6 months of MRI were identified (mean age=14 (7-20) years). Average time between MR and echo studies was 2.3±1.4 months. MRI was performed on a 1.5T MR-system (Aera, Siemens, Erlangen, Germany). TPM were acquired data in short axis orientation using a black-blood prepared cine phase-contrast sequence with tri-directional phase encoding (venc=25cm/sec, temporal resolution=24msec, spatial res=2.9x2.4mm, slice thickness=8mm). Analysis included manual segmentation of the left ventricular contours and transformation of the acquired tri-directional velocities into radial, circumferential, and long-axis velocities.
Echocardiograms were reviewed retrospectively. Mid-chamber short axis images with adequate endocardial visualization were selected. 2-dimensional STE assessment was performed offline using TomTec Image Arena (version 4.3) with determination of peak radial velocities and time-to-peak (TTP) analysis for both systole and diastole. Assessments were performed during a single cardiac cycle with imaging frame rate of 30 frames per second.
To directly compare regional velocities, data from both modalities were mapped onto the mid-ventricular section of the AHA 16-segment model and systolic and diastolic radial peak velocities as well as TTP were calculated for each segment. Inter-modality differences for peak velocities and TTP were assessed using paired t-tests; p<0.05 was considered significant.
Comparison of average peak and TTP velocities between TPM MRI and STE. (TTP - time to peak; TPM - tissue phase mapping; STE - speckle tracking echo; Std - standard deviation).
Peak Velocity [cm/s]
Peak Velocity [cm/s]
Regional myocardial velocities in pediatric patients can be measured by TPM and results correlate well with STE. Comparisons of regional velocities are similar, but systematically underestimated by STE. Diastolic TTP showed no significant difference. Further studies are needed to identify factors that may contribute to these differences.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.