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Validation of in vivo 2D Displacements from Spiral Cine DENSE at 3T
© Wehner et al; licensee BioMed Central Ltd. 2015
- Published: 3 February 2015
- Peak Strain
- Displacement Accuracy
- Stimulate Echo
- Cardiac Magnetic Resonance Technique
- Cardiac Displacement
Displacement Encoding with Stimulated Echoes (DENSE) is a cardiac magnetic resonance technique that encodes tissue displacement into the phase of the magnetic resonance signal. Due to the stimulated echo acquisition, the signal to noise ratio is low and fades through the cardiac cycle due to T1 relaxation. To compensate, a spiral cine DENSE sequence has been developed and used at 1.5T. This spiral sequence has not been validated at 3T, where increased field inhomogeneities and off resonance effects may result in measurement errors. We hypothesized that spiral cine DENSE is valid at 3T and tested this hypothesis by measuring displacement errors at both 1.5T and 3T in vivo.
The same spiral cine DENSE acquisition that has been used at 1.5T for quantification of cardiac displacements can be applied at 3T with equivalent accuracy. The inter-observer variability and agreement of DENSE-derived peak strains and torsion with HARP is also comparable at both field strengths. Future studies with spiral cine DENSE may take advantage of the additional SNR at 3T.
This work was supported by a National Institutes of Health (NIH) Director's Early Independence Award (DP5 OD-012132), NIH grant number T32 HL-072743, and NIH grant numbers UL1TR000117 and KL2 RR033171 from the National Center for Research Resources and the National Center for Advancing Translational Sciences. The content is solely the responsibility of the authors and does not necessarily represent the official views of NIH.
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