- Walking poster presentation
- Open Access
CMR myocardial tissue characterization in a mouse model of doxorubicin-induced cardiotoxicity
© Allen et al; licensee BioMed Central Ltd. 2015
- Published: 3 February 2015
- Gadopentetate Dimeglumine
- Inversion Recovery Sequence
- Cardiac Function Deterioration
- Variable Flip Angle
- Left Ventricular Base
Cardiotoxicity is a major limiting factor preventing dose-effective use of multiple cytotoxic agents in cancer treatment. Current cardiotoxicity diagnosis is based on functional changes that occur late in the course of the disease. In this pre-clinical pilot study, we hypothesize myocardial T1 and T2 mapping will identify mice at risk of death secondary to doxorubicin-induced cardiotoxicity prior to cardiac function deterioration.
Average myocardial T2 in mice undergoing IP chemotherapy was significantly correlated with outcome, while T1 and EF showed no correlation. The trends identified in this pre-clinical pilot study further drive the hypothesis that myocardial tissue characterization may be an effective tool for diagnosis and risk-stratification of chemotherapy-induce cardiotoxicity.
Northwestern CTI Pilot Grant, NIH/NCI R25 CA 132822.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.