- Walking poster presentation
- Open Access
Improved 2D slice-interleaved flow-independent cardiac black blood imaging using Ferumoxytol
© Lu et al; licensee BioMed Central Ltd. 2015
- Published: 3 February 2015
- Iron Deficiency Anemia
- Short Axis Slice
- Blood Signal
- Turbo Spin Echo
- Echo Train Length
Double inversion recovery (DIR) is the most commonly used black blood (BB) preparation method. However its single slice nature makes the acquisition inefficient and flow-dependence causes insufficient blood suppression when stagnant blood or in-plane blood flow is present. In this work, we propose to use ferumoxytol, an FDA approved iron oxide particle for treating iron deficiency anemia, as an MR contrast agent to achieve flow-independent BB imaging by taking advantage of its strong R2 relaxivity. As our technique eliminates the need for DIR preparation, we propose to achieve higher scan efficiency by interleaving the imaging slices.
Compared to conventional DIR BB imaging, the proposed ferumoxytol-enhanced slice-interleaved TSE technique provides improved blood signal suppression that does not depend on flow and is at least 3X faster than conventional DIR for the same anatomical coverage. It also provides higher SNR and CNR due to signal boost from ferumoxytol.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.