Skip to main content

Pilot data of right ventricular myocardial T1 quantification by free-breathing fat-water separated dark blood saturation-recovery imaging

Background

Right ventricular (RV) T1 quantification is desirable in managing congenital heart disease and pulmonary hypertension patients where RV fibrosis is implicated. RV T1 quantification is technically difficult because of the thin trabeculated mobile wall of complex geometry, impacted by adjacent blood and epicardial fat, plus proximity to sternal wires in some cases. Prior work has measured RV T1 by multi-shot segmented imaging1, further by IDEAL fat-water separation in SASHA extended to suppress blood signal by inflow of saturated blood.2 We present initial results by single-shot imaging with motion-corrected (MoCo) averaging aiming to: 1) reduce ghost artifacts arising in a segmented scan, 2) apply fat-water separation, 3) null blood within the RV, 4) facilitate anchor image acquisition and 5) permit free-breathing acquisition.

Methods

Data for five healthy volunteers was acquired during free-breathing (FB) on a 1.5T Siemens Avanto by MoCo averaging of fat-water separated single-shot scans.3 Dark blood motion-sensitized4 preparation (MSPrep) parameters and feasibility were investigated.

Saturation recovery sampling5 was applied to FB acquisitions of a single short-axis slice across the RV free wall. The sampling comprised four 20-cycle scans at Ts≈600ms and two anchor scans at Ts>6sec (20 cycles acquired with long recovery gaps), all repeated three times per subject for intra-session reproducibility (Figure 1). Complex MoCo averaging6 was configured at fixed 50% acceptance i.e. the 10 shots at most similar respiratory phase. Imaging parameters were: TE=1.0, 2.7, 4.3ms, FA 20°, FOV 360x270mm, 6x1.9x2.5mm acquired voxels, TGRAPPA rate 3, requiring a diastolic shot duration 190ms.

Figure 1
figure1

Normal volunteer RV T1 by fat-water separated, MSPrep dark blood imaging: A) MoCo averaged water-only image at Ts 600ms, B) MoCo averaged water-only anchor image at same window/level, C) MoCo averaged fat only image, D) T1 map generated from registration and 2-point fit of the six images per sampling scheme.

Optimised BIR-4 saturation efficiency η was <0.5% of M0 over typical 1.5T cardiac B0 and B1 distortion. The MSPrep aimed to null blood signal by through-slice velocity-sensitized dephasing without losing myocardial signal, by adjustable time of application and velocity-sensitivity Field-of-Speed4. Mean RV free wall and septal T1s were independently measured by two observers from 2-parameter fit pixelwise maps assuming η=1.

Results

Moderate free-breathing reproducibility of RV T1 was demonstrated (Table 1). There was usually an underestimate of myocardial T17 and often a currently unexplained non-uniformity of T1 across the heart. The MSPrep generally nulled blood when applied typically 50ms after the start of diastasis, with FoS 10-25cm/s. However, subject-specific optimisation of both MSPrep parameters was necessary to null blood while avoiding myocardial signal loss.

Table 1 Myocardial T1 values in volunteers reported as mean ± standard deviation (SD) with coefficient of variation (CoV = SD/mean x100%). FB: free breathing, RV: right ventricle, LV: left ventricle

Conclusions

Although FB RV T1 quantification is feasible with the proposed method, further technical development work is required and underway towards improved precision and accuracy.

Funding

British Heart Foundation, NIHR Cardiovascular Biomedical Research Unit of Royal Brompton & Harefield NHS Foundation Trust and Imperial College London.

References

  1. 1.

    Mehta : MRM. 2014

    Google Scholar 

  2. 2.

    Pagano : ISMRM. 2014

    Google Scholar 

  3. 3.

    Kellman : MRM. 2009

    Google Scholar 

  4. 4.

    Nguyen : JMRI. 2008

    Google Scholar 

  5. 5.

    Kellman : JCMR. 2014

    Google Scholar 

  6. 6.

    Ledesma-Carbayo : JMRI. 2007

    Google Scholar 

  7. 7.

    Chow : MRM. 2014

    Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Ee Ling Heng.

Rights and permissions

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Heng, E.L., Kellman, P., Gatzoulis, M.A. et al. Pilot data of right ventricular myocardial T1 quantification by free-breathing fat-water separated dark blood saturation-recovery imaging. J Cardiovasc Magn Reson 17, Q23 (2015). https://doi.org/10.1186/1532-429X-17-S1-Q23

Download citation

Keywords

  • Right Ventricular
  • Pulmonary Hypertension Patient
  • Right Ventricular Free Wall
  • Myocardial Signal
  • Dark Blood