Inter-study reproducibility of interleaved spiral phase velocity mapping of renal artery haemodynamics
Journal of Cardiovascular Magnetic Resonance volume 17, Article number: Q39 (2015)
Renal resistive index (RI) and pulsatility index (PI) are reliable measures of downstream renal resistance which correlate with the severity of renal disease. To date, MR phase velocity mapping studies have lacked the temporal resolution required to determine these pulsatility parameters. Our aim is to develop a high temporal resolution breath-hold spiral phase velocity mapping technique for assessment of the temporal flow patterns in renal arteries and to determine inter-study reproducibility.
An interleaved spiral phase velocity mapping sequence was developed on a 3T Skyra scanner (Siemens) using 1-1 water excitation and with full k-space coverage in 8 spiral interleaves of 12 ms duration. Phase map subtraction of datasets with symmetric bi-polar velocity encoding gradients resulted in velocity maps with a through-plane phase sensitivity of +/- 150cm/s. Retrospectively ECG gated data were acquired in a 17 cardiac cycle breath-hold (includes 1 dummy cycle) with a spatial resolution of 1.4 x 1.4 mm (reconstructed to 0.7 x 0.7 mm) and a repeat time of 19 ms. Renal artery velocity maps were acquired in 10 healthy volunteers (10 left and 10 right arteries). Data were acquired in each of two separate scanning sessions with the volunteer leaving the scanner between sessions. For each acquisition (40 in total), RI and PI were calculated by 2 observers as follows:
RI = (PSV - MDV) / PSV
PI = (PSV - MDV) / MV
where PSV = peak systolic velocity, MDV = minimum diastolic velocity and MV = mean velocity through the cardiac cycle
Background phase errors were determined from (i) a large stationary phantom acquisition and (ii) by fitting a background phase map to user defined stationary points in the inter-vertebral disks. Inter-observer and inter-study reproducibility of RI, PI and renal artery blood flow (RABF) per kidney were determined as the mean (+/- standard deviation) of the paired differences between observers and between scanning sessions and by the intraclass correlation coefficient (ICC).
Figure 1 shows example data. RI, PI and RABF per kidney were 0.71+/- 0.06, 1.47 +/- 0.29 and 413 +/- 122 ml/min respectively. Inter-observer and inter-study Bland Alman plots are shown in Figure 2. The inter-study reproducibilities were: RI -0.00 +/- 0.04 , PI -0.03 +/- 0.17, and RABF per kidney 17.9 +/- 44.8 ml/min. Inter-study ICCs (observers 1 and 2 respectively) were 0.87 and 0.86 (RI), 0.92 and 0.93 (PI) and 0.96 and 0.95 (RABF). The effect of background phase correction was negligible (<2% for each parameter).
High temporal resolution breath-hold spiral phase velocity mapping allows reproducible assessment of renal pulsatility indices and RABF. We conclude that this technique is suitable for studying temporal flow velocity patterns in the renal arteries.
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Keegan, J., Patel, H., Simpson, R. et al. Inter-study reproducibility of interleaved spiral phase velocity mapping of renal artery haemodynamics. J Cardiovasc Magn Reson 17 (Suppl 1), Q39 (2015). https://doi.org/10.1186/1532-429X-17-S1-Q39