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LV rotational mechanics in patients with dilated cardiomyopathy compared to healthy individuals: Experience from the European CMR Registry

Background

Left ventricular rotation is an important part of myocardial mechanics during the cardiac cycle. Understanding the mechanisms of LV rotation in different cardiac diseases could play an important role for diagnosis, risk stratification and prediction of heart failure. We sought to analyze LV rotation using the feature tracking technique in patients with dilated cardiomyopathy (DCM) included in the European CMR Registry.

Methods

82 Patients diagnosed with DCM and a control group consisting of 30 healthy volunteers were analyzed using dedicated feature tracking imaging software (2D CPA MR©, TomTec Imaging Systems GmbH). An apical, midventricular and basal slice in short axis orientation were tracked to analyze the peak rotation of each slice. LV twist (defined as the difference of peak apical and peak basal rotation at isochronal time points) and LV torsion (defined as the LV twist per ventricular length) were calculated.

Results

DCM patients and controls with normally directed rotation (counterclockwise apical and clockwise basal rotation) were compared to each other (table 1): DCM patients showed significantly lower apical and basal rotation resulting in significantly lower LV twist and LV torsion.

Table 1 Comparison of DCM patients and the control group with normally directed rotation

Amongst the DCM patients an inversed rotational pattern was frequently observed (Table 2): 57.3% of DCM patients showed a normal direction of rotation, compared to 80% of the control group. 30.5% of patients with DCM and 3.3% of the control group showed inversed clockwise apical rotation. 16.7% of the healthy volunteers showed an inversed counterclockwise rotation of the basis compared to 9.8% of patients with DCM. An inversed rotation in opposite directions of both, the apical and the basal layer, was present in 2.4% of DCM patients, but not in control subjects.

Table 2 Direction of rotation: Distribution of DCM patients and the control group

Conclusions

DCM is associated with an inverted direction of rotation in a significant amount of cases, predominantly affecting the LV apex. Patients with a normal direction of rotation exhibit significant lower torsion. These findings warrant further investigation including clinical follow-up data in order to analyze their impact on clinical outcome in patients with DCM.

Funding

N/A.

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Correspondence to Andreas Ochs.

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Ochs, A., Schuster, A., Riffel, J. et al. LV rotational mechanics in patients with dilated cardiomyopathy compared to healthy individuals: Experience from the European CMR Registry. J Cardiovasc Magn Reson 17, Q69 (2015). https://doi.org/10.1186/1532-429X-17-S1-Q69

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Keywords

  • Dilate Cardiomyopathy
  • Feature Tracking
  • Basal Rotation
  • Apical Rotation
  • Short Axis Orientation