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Kinetic energy efficiency of single ventricle and TCPC using 4D flow MRI
© Roldán-Alzate et al; licensee BioMed Central Ltd. 2015
- Published: 3 February 2015
- Energy Efficiency
- Single Ventricle
- Vessel Segmentation
- Systemic Ventricle
- Total Cavopulmonary Connection
Altered hemodynamics in total cavopulmonary connection (TCPC), a palliation of single ventricle defects, results in long-term complications, such as decreased exercise capacity, arrhythmia, and ventricular failure . Non-invasive hemodynamic evaluation of TCPC has been an important clinical challenge. Several studies have tried to understand and predict specific flow features using a combination of patient-specific MRI data and computational tools to develop more realistic numerical and physical models. Most numerical studies have based their analyses of TCPC efficiency on energy loss calculations, but assumptions such as rigid walls and idealized flow conditions might affect accuracy hindering clinical applicability . The purpose of this study was to calculate kinetic energy (KE) from in vivo 4D Flow MRI velocity measurements, in the TCPC and single ventricle for assessing efficiency of the system.
As expected, TCPC patients had less systemic efficiency; however, high variability was observed in both groups suggesting the need for larger sample studies. Successful implementation of in vivo 4D Flow MRI provides a powerful non-invasive surveillance tool that has the potential to allow the clinician to follow the performance of TCPC over time, identify potential hemodynamic deterioration and intervene in an asymptomatic phase to increase the life span of the operation.
American Heart Association - Scientist Development Grant (Alejandro Roldán-Alzate).
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.