Accelerated and KWIC-filtered cardiac T2 mapping for improved precision: proof of principle
Journal of Cardiovascular Magnetic Resonance volume 17, Article number: W30 (2015)
In recent years, several successful variations of T2-prepared cardiac T2 mapping techniques have been described for the quantification of cardiac edema [1,2,3]. Radial imaging for high-resolution T2 mapping  has the advantage of reduced motion sensitivity, but suffers from a lower signal-to-noise ratio (SNR) due to the undersampling of the periphery of k-space and the density compensation function (DCF) that increases the weight of the relatively noisy and less densely sampled k-space periphery (Fig.1a). Since the contrast of an image is defined by the center of k-space, a KWIC (k-space weighted image contrast ) filter can be used to share only the periphery among radial images that have the same geometry and different contrast, such as those used to generate a T2 map (Fig.1b). Furthermore, when undersampling is used to acquire more images per T2 map (resulting in more k-space peripheries that can be shared), KWIC filtering further reduces the noise-like undersampling artifacts (Fig.1c). The goal of this study was therefore to test whether the use of the KWIC filter leads to a higher precision in radial T2 maps for a given acquisition time.
Standard navigator-gated radial T2 maps at 3T (Siemens Skyra) were acquired with 3 T2Prep durations, 308 radial lines with golden-angle increment per image, matrix 256x256, and spatial resolution (1.17mm)2  in an agar-NiCl2 phantom with relaxation times that approximated myocardium and blood. Subsequently, T2 maps at the same location were acquired with 6 T2Prep durations, with 308 and 110 lines per image. T2 maps were reconstructed both with and without the KWIC filter. The T2 standard deviations (σT2) of the myocardial compartment in the resulting T2 maps were then compared. Finally, the same protocol was applied for the myocardium in 3 healthy volunteers.
All phantom T2 maps could be successfully reconstructed (Fig.2a). The KWIC-filtered and undersampled T2 map was acquired in 72% of the standard acquisition time, and resulted in a σT2 decrease from 2.1 to 1.2ms (Fig.2b). The acquisitions in the volunteers were similarly successfully reconstructed, and the resulting T2 values and σT2 for the KWIC-filtered T2 maps (38.7±3.3ms) did not differ from the standard T2 maps (37.6±3.1ms, Fig. 2c&d).
The phantom study demonstrated that the application of the KWIC filter to radial T2 mapping allows for a shortening of the acquisition time together with an increase in precision. The equivalency of the KWIC-filtered protocol in vivo might be caused by the lower overall SNR that is exacerbated by the undersampling, although this needs to be investigated in a larger cohort.
Emma Muschamp Foundation (RBvH).
Foltz : MRM. 2003
Giri : JCMR. 2009
van Heeswijk : JACCImaging. 2012
Song : MRM. 2000
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Lugand, E., Yerly, J., Feliciano, H. et al. Accelerated and KWIC-filtered cardiac T2 mapping for improved precision: proof of principle. J Cardiovasc Magn Reson 17 (Suppl 1), W30 (2015). https://doi.org/10.1186/1532-429X-17-S1-W30