- Workshop presentation
- Open Access
Free-breathing myocardial T2* mapping using GRE-EPI and automatic non-rigid motion correction
© Jin et al; licensee BioMed Central Ltd. 2015
- Published: 3 February 2015
- Respiratory Motion
- Cardiac Iron
- Respiratory Motion Artifact
- Water Excitation
- Cardiac Iron Overload
Myocardial T2* mapping is a widely used method to detect and quantify cardiac iron overload in transfusion-dependent anemia patients (1, 2). The ECG-triggered black-blood multi-echo gradient echo sequence typically used for myocardial T2* mapping acquires segmented k-space data across multiple heart beats (BH Seg-mGRE) (3). However, it is highly sensitive to respiratory motion and requires patient breath-hold. In this work, we present a new free-breathing technique to accurately quantify myocardial T2* by acquiring multiple, single heartbeat images insensitive to respiratory motion artifact, and applying automatic non-rigid motion correction (moco GRE-EPI) to register images prior to T2* map estimation.
We developed a black-blood, multi-shot, GRE-EPI sequence with TR = 20 ms, echo-train-length = 5, GRAPPA acceleration rate = 2 and a water excitation pulse to minimize fat displacement artifacts. Eight images were acquired at echo times ranging from 1.2 ms to 15 ms; each T2*-weighted image was acquired in one heartbeat with an acquisition window of 240 ms and repeated with four measurements. The total acquisition duration was 64 heart beats. Automatic in-plane non-rigid motion correction (4, 5) was used to compensate for mis-registration due to respiratory motion. Motion correction (moco) was applied first across the four measurements at each TE prior to averaging, and then across the averaged images at different TEs prior to generating the T2* map. T2* maps were calculated by fitting a mono-exponential model. Both acquisition techniques were attempted in 72 patients referred for clinical CMR cardiomyopathy evaluation on the 1.5 T scanner (Avanto, Siemens). Both moco GRE-EPI during free-breathing and BH Seg-mGRE during breath-hold were acquired in a single mid-short axis plane. T2* was measured in the interventricular septum and liver.
We have described a technique for T2* mapping using moco GRE-EPI that enables accurate myocardial T2* measurements and is insensitive to respiratory motion. It could be especially beneficial for patients who are unable to breath-hold.
- Zurlo MG: Lancet. 1989, 8653: 27-30.View ArticleGoogle Scholar
- Anderson LJ: Eur Heart J. 2001, 22: 2171-2179. 10.1053/euhj.2001.2822.View ArticlePubMedGoogle Scholar
- He T: JMRI. 2007, 25: 1205-1209. 10.1002/jmri.20929.View ArticlePubMedGoogle Scholar
- Guetter : ISBI. 2011Google Scholar
- Kellman : MRM. 2009, 62: 1557-1564. 10.1002/mrm.22153.PubMed CentralView ArticlePubMedGoogle Scholar
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