- Oral presentation
- Open Access
High efficiency coronary MRA with non-rigid cardiac motion correction: beyond the quiescent period
© Pang et al. 2016
- Published: 27 January 2016
- Motion Correction
- Cardiac Motion
- Cardiac Phasis
- Quiescent Period
- Respiratory Motion Artifact
Coronary arteries remain challenging structures to image using MRI due to the small size, tortuous course, and continual motion. Current high-resolution whole-heart techniques use prospective ECG-triggering and navigator gating to suppress cardiac and respiratory motion artifacts, respectively. However, these motion suppression strategies only accept data acquired within a narrow window in the cardiac and respiratory cycles, resulting in low scanning efficiency and prolonged scan time. Recent works use respiratory motion correction to achieve 100% respiratory gating efficiency [1–3]. In this work, we extend this concept and develop a non-rigid cardiac motion correction method to extend the cardiac acceptance window beyond the quiescent period.
MR data was collected using a contrast-enhanced spoiled gradient echo sequence with 3D radial trajectory and retrospective cardiac and respiratory self-gating, from which 16 cardiac phases were reconstructed with affine respiratory motion correction . Next, all diastolic phases are registered to mid-diastole using a symmetric diffeomorphic model . Then, motion-corrected reconstruction is accomplished by inverting the encoding operator that includes sensitivity encoding and warping the target image to different cardiac phases . Healthy subjects (N = 7) were scanned using a clinical 3T scanner (Siemens Verio). Three images are reconstructed from each dataset: mid-diastole quiescent window, extended window without motion correction, and extended window with motion correction. The scan efficiency, coronary sharpness, and apparent signal-to-noise ratio (aSNR) are compared using paired Student's t-test with a significance level of 0.05.
In this work, we developed a cardiac motion correction framework for high-efficiency coronary MRA, allowing the cardiac acceptance window to be significantly widened while minimizing the artifacts from cardiac motion. The higher scan efficiency can be used to improve the image quality, as shown by our preliminary in vivo studies, or potentially reduce the scan time. Future developments will be focused on optimizing the registration parameters, and further validations on both healthy and patient subjects.
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