- Oral presentation
- Open Access
Simultaneous multi-slice excitation for single breath hold estimates of left ventricular rotational mechanics
© Wang et al. 2016
- Published: 27 January 2016
- Rotational Mechanic
- Single Breath Hold
- Left Ventricular Apex
- Left Ventricular Twist
- Left Ventricular Peak
Quantitative measurements of left ventricular (LV) rotational mechanics can be estimated from cardiac tagged images and provide early insight into LV dysfunction. Current clinical protocols acquire tagged images at the LV apex and the LV base in two separate breath-held scans, which can contribute measurement bias due to differences in cardiac loading conditions. The first objective was to implement Simultaneous Multi-Slice (SMS) excitation (Felix A.B. et al. MRM 53:684-691 2005) for cardiac tagging to permit simultaneous acquisition of two short-axis grid tagged images. The second objective was to compare a conventional Multi Breath Hold (MBH) protocol to a Single Breath Hold (SBH) SMS protocol and evaluate the respective repeatability in healthy volunteers.
A cardiac tagging sequence, which uses non-selective RF pulses to generate grid tag patterns throughout the heart, was modified to support SMS. The sequence was evaluated in an IRB approved study after obtaining consent from ten (N = 10) healthy human subjects with 15 heartbeat acquisition using the following parameters: 330-400 × 330-400 mm FOV, 6 mm slice thickness, TE/TR = 4.5/5.3 ms, 12° flip angle, 1.8 × 1.8 mm resolution, 250 Hz/pixel bandwidth, 8 phase encode lines per segment on a 1.5T scanner (Siemens Avanto). Simultaneous basal and apical images were acquired through mid-diastole (~750 ms). SMS images were reconstructed using a Matlab toolbox (Setsompop, K. et al. MRM 67, 1210-1224). Conventional MBH grid tags were also acquired. Each method was repeated twice. LV twist measurements were calculated using the FAST method (Reyhan M. et al. JMRI 2012 35:587-593). Both MBH and SBH acquisitions were repeated in random order. Repeatability results were compared using a t-test and Bland-Altman analysis.
Since the tagging preparation pulses are non-selective, SMS and cardiac tagging can be combined into a single breath-held acquisition. The SBH SMS approach resulted in similar estimates of peak LV twist with improved repeatability in half the scan time compared to the MBH approach.
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