- Oral presentation
- Open Access
Improved dynamic contrast-enhanced magnetic resonance angiography (CE-MRA) using iterative data reconstruction
© D'Errico et al. 2016
- Published: 27 January 2016
- Iterative Reconstruction
- Iterative Reconstruction Technique
- Thoracic Aortic Pathology
- Siemens Healthcare GmbH
- Large Arterial Vessel
CE-MRA following the injection of a gadolinium-based contrast agent (GBCA) bolus is widely used in clinical assessment of vascular dynamics and tissue perfusion (1,2). Although keyhole techniques with an increased number of central k-space updates further improved contrast kinetics information, spatial resolution remains limited. Alternatively applied view sharing approaches also result in prolonged temporal footprints with possible temporal blurring or reconstruction artifacts. Sparse, incoherent sampling approaches and iterative reconstruction techniques have proven successful particularly in dynamic MR imaging (3). We sought to evaluate the impact of iterative reconstruction techniques on dynamic contrast enhanced MRA of the thoracic aorta.
Dynamic MRA data sets of 11 patients acquired for thoracic aortic pathology at 3T (MAGNETOM Skyra fit, Siemens Healthcare GmbH) were included. Standard parasagittal TWIST was employed with a slab thickness of 105.6 mm. K-Space coverage employed a central k-space region (A-15%) and differently sampled peripheral k-space regions (B-20%, B1-B5) after bolus injection (3 ml/s) of 2 ml Gadobutrol diluted with 6 ml NaCl. With a spatial resolution of 1.2 × 1.0 × 1.2 mm3 (interpolated to 1 mm3) and R = 4 × 2 GRAPPA acceleration acquisition time for each partial k-space (A/B1-B5) was 1.2 s. Standard (TWIST) and prototype iterative algorithm reconstruction (IT-TWIST) was performed on k-space raw data. TWIST was followed by accelerated static MRA (GRAPPA R = 3) with 0.9 × 0.9. × 1.2 mm3 resolution in 22 s acquisition time (32 ml of 1:3 diluted Gadobutrol, 3 ml/s). All TWIST and static MRA were visually assessed (5-point Likert scale) by two blinded readers for contrast-to-noise (CNR), vessel delineation and pulmonary vasculature quality (TWIST/IT-TWIST only). Wilcoxon rank sum test was used for statistical comparison.
Iterative reconstruction substantially improves mid/small vessel delineation in dynamic CE-MRA. This combination overcomes the limitation of poor dynamic pulmonary MRA at 3T with standard reconstruction techniques. It has the potential to eliminate the need for bolus timing, to reduce GBCA volume and to eventually replace static MRA.
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