- Oral presentation
- Open Access
Quantifying right ventricular diffuse fibrosis in tetralogy of Fallot - a novel customised approach for the challenges of the right ventricle
© Heng et al. 2016
- Published: 27 January 2016
- Right Ventricular
- Right Ventricular Free Wall
- Diffuse Fibrosis
- Right Ventricular Wall
- Shot Duration
There are clear clinical drivers for right ventricular (RV) T1 mapping in patients with repaired tetralogy of Fallot (rTOF), in whom myocardial fibrosis is implicated in adverse clinical outcomes. However, considerable technical challenges exist, due to thin mobile RV wall with adjacent strong signals from blood and epicardial fat. We prospectively aimed to explore the possible clinical significance of RV diffuse fibrosis in rTOF compared to health.
Data for 22 subjects (11 patients with rTOF and 11 age and gender-matched healthy volunteers) were acquired. Two-parameter fit pixelwise T1 maps were generated for each run. Mean RV free wall T1s were measured by two independent observers using CMR42. Inter-observer reproducibility was calculated by coefficient of variation (CoV%) = (within-subject standard deviation/mean) x100%.
RV T1 and ECV quantification is possible with the proposed technique but requires further development. The diagnostic value in this patient population merits further work towards a larger study and to explore histological correlation.
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