| |
AS Patients (n = 174)
|
Healthy Controls (n = 23)
|
p-value
|
|---|
|
Age (years)
|
66.2 ± 13.3
|
68.3 ± 8.8
|
0.331
|
|
Male (n (%))
|
133 (76.4)
|
16 (69.6)
|
0.471
|
|
Echocardiography data
|
|
AV Vmax (m/s)
|
3.86 ± 0.56
|
1.35 ± 0.27
|
<0.001*
|
|
AVAI (cm2/m2)
|
0.57 ± 0.14
|
1.71 ± 0.36
|
<0.001*
|
|
Lateral E/e'
|
9.88 ± 3.72
|
8.07 ± 2.97
|
0.026*
|
|
VAI (Echo) (mmHg/ml/m2)
|
3.96 ± 1.06
|
3.67 ± 0.76
|
0.220
|
|
CMR data
|
|
LVEDVI (ml/m2)
|
87.58 ± 18.27
|
78.16 ± 9.40
|
<0.001*
|
|
LVESVI (ml/m2)
|
38.28 ± 10.65
|
32.11 ± 5.03
|
<0.001*
|
|
LVEF (%)
|
56.7 ± 4.95
|
58.9 ± 3.67
|
0.044*
|
|
LVMI (g/m2)
|
57.69 ± 13.85
|
44.31 ± 7.20
|
<0.001*
|
|
LV mass/volume (g/ml)
|
0.66 ± 0.11
|
0.57 ± 0.08
|
<0.001*
|
|
VAI (MRI) (mmHg/ml/m2)
|
3.81 ± 0.82
|
3.50 ± 0.74
|
0.078
|
|
Global MPR
|
2.27 ± 0.70
|
3.16 ± 0.65
|
<0.001*
|
|
LGE present (n,%)
|
82 (47.1)
|
5 (21.7)
|
0.025*
|
|
% LGE (%)
|
4.20 ± 3.76
|
2.00 ± 2.21
|
<0.001*
|
|
Native myocardial T1 (ms)
|
1131.9 ± 69.54
|
1092.3 ± 34.29
|
<0.001*
|
|
ECV (%)
|
24.82 ± 2.43
|
25.05 ± 2.57
|
0.680
|
- AV Vmax=peak aortic jet velocity, AVAI=aortic valve area indexed to BSA, VAI=valvulo-arterial impedance, LVEDVI=left ventricular end-diastolic volume indexed to BSA, LVESVI=left ventricular end systolic volume indexed to BSA, LVEF=left ventricular ejection fraction, LVMI=left ventricular mass indexed to BSA, MPR=myocardial perfusion reserve, LGE=late gadolinium enhancement, ECV=extracellular volume fraction
