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Table 1 Demographic, echocardiographic and CMR data for patients and controls

From: Myocardial Perfusion Reserve but not fibrosis predicts outcomes in initially asymptomatic patients with moderate to severe aortic stenosis: the PRognostic Importance of MIcrovascular Dysfunction in AS study- PRIMID AS

 

AS Patients (n = 174)

Healthy Controls (n = 23)

p-value

Age (years)

66.2 ± 13.3

68.3 ± 8.8

0.331

Male (n (%))

133 (76.4)

16 (69.6)

0.471

Echocardiography data

AV Vmax (m/s)

3.86 ± 0.56

1.35 ± 0.27

<0.001*

AVAI (cm2/m2)

0.57 ± 0.14

1.71 ± 0.36

<0.001*

Lateral E/e'

9.88 ± 3.72

8.07 ± 2.97

0.026*

VAI (Echo) (mmHg/ml/m2)

3.96 ± 1.06

3.67 ± 0.76

0.220

CMR data

LVEDVI (ml/m2)

87.58 ± 18.27

78.16 ± 9.40

<0.001*

LVESVI (ml/m2)

38.28 ± 10.65

32.11 ± 5.03

<0.001*

LVEF (%)

56.7 ± 4.95

58.9 ± 3.67

0.044*

LVMI (g/m2)

57.69 ± 13.85

44.31 ± 7.20

<0.001*

LV mass/volume (g/ml)

0.66 ± 0.11

0.57 ± 0.08

<0.001*

VAI (MRI) (mmHg/ml/m2)

3.81 ± 0.82

3.50 ± 0.74

0.078

Global MPR

2.27 ± 0.70

3.16 ± 0.65

<0.001*

LGE present (n,%)

82 (47.1)

5 (21.7)

0.025*

% LGE (%)

4.20 ± 3.76

2.00 ± 2.21

<0.001*

Native myocardial T1 (ms)

1131.9 ± 69.54

1092.3 ± 34.29

<0.001*

ECV (%)

24.82 ± 2.43

25.05 ± 2.57

0.680

  1. AV Vmax=peak aortic jet velocity, AVAI=aortic valve area indexed to BSA, VAI=valvulo-arterial impedance, LVEDVI=left ventricular end-diastolic volume indexed to BSA, LVESVI=left ventricular end systolic volume indexed to BSA, LVEF=left ventricular ejection fraction, LVMI=left ventricular mass indexed to BSA, MPR=myocardial perfusion reserve, LGE=late gadolinium enhancement, ECV=extracellular volume fraction