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- Open Access
Relationship between the transmural extent of high resolution parametric (T1- and T2) mapping and the ischemic area at risk defined by pathology
© Wendell et al. 2016
- Published: 27 January 2016
- Myocardial Infarction
- Acute Myocardial Infarction
- Partial Volume Effect
- Resolution Parametric
- Abnormal Region
Delineating the area-at-risk (AAR) is crucial in determining the amount of salvaged myocardium following an acute myocardial infarction (MI). Myocardial parametric mapping (native T1- and T2-mapping) has been promoted as an excellent method to delineate the AAR, and image reproducibility appears to be superior to that for black-blood TSE imaging . However, robust validation of these techniques with a direct comparison of the transmural shape of the AAR by pathology with the transmural shape of the abnormal regions in parametric maps has not been performed.
We used a canine model of acute MI with variable coronary occlusion times (40-90 min) to create a range of infarct sizes and transmurality (n = 12). We obtained high spatial resolution T1 and T2 maps (0.75 × 0.75 × 6 mm) to reduce the magnitude of partial volume effects in altering T1 and T2 measurements. CMR was performed 2-5 days following MI at 3T (Siemens Verio). The AAR and MI were delineated by pathology using microspheres and TTC staining, respectively. Abnormal regions on MRI were compared to pathology by quantitative measurement of the transmural-extent of the abnormality (abnormal area/sector area). T1 and T2 values were measured within the infarcted and salvaged portions of the AAR and in remote myocardium. CMR was also performed in five patients with acute MI for which imaging and analysis were performed similar to that for canines.
With high resolution T1 and T2 mapping, no relationship was seen between the transmural extent of T1 and T2 abnormalities and that of the AAR by pathology. Instead there was a strong correlation with the transmural extent of infarction. The use of native T1 and T2 mapping to delineate the AAR is problematic.
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