- Oral presentation
- Open Access
High-resolution late gadolinium enhancement imaging with compressed sensing: a single-center clinical study
© Akcakaya et al. 2016
- Published: 27 January 2016
- Late Gadolinium Enhancement
- Image Quality Assessment
- Subjective Image Quality
- Late Gadolinium Enhancement Imaging
- Isotropic Resolution
Late gadolinium enhancement (LGE) MRI is the clinical standard for imaging of scar in the left ventricle (LV). It has also been employed for assessing RF ablations in the left atrium (LA). LV LGE imaging is typically performed in 2D. When 3D is utilized, spatial resolution is limited due to prolonged scan time. We have shown that an accelerated imaging technique called LOST with random undersampling can be used to achieve isotropic resolution in 3D LGE. To benefit from this novel technique and the resolution gains, reconstruction needs to be automated and integrated into clinical workflow. In this study, we sought to utilize random undersampling and LOST reconstruction, with a novel software tool that enables clinically feasible integration, in order to enable LGE MRI with high isotropic spatial resolution in the clinical setting in a large cohort of patients.
In a prospective study, 270 patients (181 men; 54.9 ± 14.1 yrs) were recruited. 190 were referred for LV LGE, and 80 for LA LGE. LGE were acquired 10-to-20 minutes after bolus infusion of 0.1-to-0.2 mmol/kg of Gd-BOPTA or Gd-DTPA. Imaging was performed at 1.5T with an ECG-triggered navigator-gated IR-GRE sequence. The isotropic resolution varied from 1 × 1 × 1 mm3 to 1.5 × 1.5 × 1.5 mm3. 3D random undersampling was used, with acceleration rates of 3 (133 patients) or 5 (137 patients), corresponding to acquisition durations of 4:00 or 2:30 minutes (70 bpm, 100% navigator efficiency).
Subjective image quality assessment was performed by an experienced blinded cardiologist. Presence of LGE was assessed as present with confidence/absent with confidence/unconfident to decide. Datasets were also assessed using a 4-point system: 1 (poor, LGE interpretable in < 50% of LV myocardium/LA), 2 (fair, LGE interpretable in 50-75% of LV/LA), 3 (good, LGE interpretable in 75-90% of LV/LA), 4 (excellent, LGE interpretable in >90% of LV/LA).
The proposed acquisition and automated reconstruction framework enables the clinical use of accelerated high isotropic resolution LGE imaging in a large number of patients.
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