- Oral presentation
- Open Access
The association of left atrial volume with age, ethnicity and cardiovascular risk factors in men and women: the Multi-Ethnic Study of Atherosclerosis (MESA)
© Zemrak et al. 2016
- Published: 27 January 2016
- Cardiovascular Risk Factor
- Cardiovascular Magnetic Resonance
- Leave Ventricular Hypertrophy
- Left Atrial
- Normal Body Mass Index
There are limited data assessing the association of demographics and cardiovascular risk factors with left atrial (LA) dimensions measured by cardiovascular magnetic resonance (CMR). The aim of this study was to determine the association of LA volume with gender, demographic factors, cardiac structure and cardiovascular risk factors.
LA volume indexed to body surface area (LAVi) was measured by CMR using steady-state free precession cine long and short axis images in 2576 participants of the Multi-Ethnic Study of Atherosclerosis (68.7 years, 53.0% women). We used gender stratified regression models to evaluate the association of LAVi as the dependent variable with demographic and cardiovascular risk factors, left ventricular (LV) parameters and diagnosis of coronary heart disease as independent variables. LAVi between ethnicities were compared using analysis of variance (ANOVA) with Tukey's post-hoc analysis. To determine normal LA dimensions we also selected a group of participants with normal body mass index (≥18.5 and < 25 kg/m2), without hypertension, diabetes, coronary heart disease, congestive heart failure, LV systolic dysfunction (defined as ejection fraction less than 50%), LV hypertrophy or atrial fibrillation (n = 285, 65.6 years, 61.8% women).
LAVi enlargement in response to age and cardiovascular diseases is different in men and women, and may be also influenced by ethnicity. However, gender did not influence LAVi in the "normal" reference cohort free of cardiovascular disease.
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