- Oral presentation
- Open Access
The kinetic energies of left ventricular 4D flow components correlate with established markers of prognosis and represent novel imaging biomarkers in both ischaemic and dilated cardiomyopathy
© Stoll et al. 2016
- Published: 27 January 2016
- Dilate Cardiomyopathy
- Cardiac Remodelling
- Residual Volume
- Established Marker
- Dilate Left Ventricle
Despite different aetiology of myocardial damage in dilated cardiomyopathy (DCM) and ischaemic cardiomyopathy (IHD), cardiac remodelling occurs in both, culminating in the end result of a dilated left ventricle with impaired function. Cardiac remodelling is a complex process in which numerous cellular, mechanical and flow processes become deranged. Insights into changes of multidimensional flow patterns and kinetic energy (KE) within the left ventricle are now afforded by the use of 4D flow CMR.
We hypothesised that greater derangements in 4D flow measures would relate to: 1) decreased mechanical cardiac function and dilatation, as assessed by LV ejection fraction (LVEF), LV myocardial strain and LV volumes, 2) increased levels of biochemical remodelling markers and 3) worsening patient symptoms and functional capacity. We hypothesised these changes to be independent of the initial aetiology of the myocardial damage, instead reflecting the self-propagating nature of cardiac remodelling.
98 subjects (34 DCM patients, 30 IHD patients and 34 healthy controls) underwent CMR imaging for anatomy, tagging and 4D flow. The LV volume was analysed in 4 functional flow components; direct flow, delayed ejection flow, retained inflow and residual volume. The kinetic energy (KE) for these components was measured at end diastole.
Both DCM and IHD patients demonstrated less efficient blood flow patterns with deranged kinetic energy profiles compared to controls. The greater the derangement of flow parameters from normal, the worse the myocardial function, dilatation, BNP, 6 MWT and patient symptoms, irrespective of the initial pathology. This is the first study to suggest that derangements in 4D flow parameters are novel biomarkers of disease severity in cardiomyopathy patients and correlate with established markers of cardiac remodelling and prognosis, which may provide additive value in monitoring novel heart failure therapies and predicting prognosis.
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