Hematocrit, iron and HDL-cholesterol explain 90% of variation in native blood T1
Journal of Cardiovascular Magnetic Resonance volume 18, Article number: O86 (2016)
Native myocardial T1 is known to be affected by variables such as age, gender, heart rate and partial voluming from blood pool. Blood T1 itself has a wide (wider) variability. We aimed to investigate causes of blood T1 variability.
77 healthy volunteers with no known cardiovascular condition underwent CMR at 1.5T (Siemens, Avanto). Mid ventricular short axis native T1 maps by MOLLI (with T1* reconstruction in addition) and ShMOLLI were acquired. Hematocrit (Hct), iron profile and lipid profile were acquired immediately prior to the scan. CVI42 (Calgary, Canada) was used for analysis of the maps. A ROI was drawn in the blood pool on the MOLLI T1 map, avoiding papillary muscles and was copied on to the MOLLI T1* and ShMOLLI T1.
Complete datasets of blood and maps were available for all 77 volunteers (mean age 49 ± 14, range 20-76, 49% males). Mean ± SD of blood T1 by MOLLI T1 was 1638 ± 78 ms, MOLLI T1* 1686 ± 111 ms and ShMOLLI T1 1543 ± 77 ms. There was a negative correlation between blood T1 and Hct (R2 0.530, coeff. -0.728, p < 0.0001)(Figure 1). Hct, iron, HDL-cholesterol, ferritin, triglycerides (TG), LDL-cholesterol and total iron binding capacity (TIBC) resulted to be significant at univariate analysis while this was not the case for albumin and total cholesterol. The multivariate analysis performed including only the significant variables showed that Hct, iron and HDL-cholesterol are significantly correlated with blood T1 by MOLLI T1 and T1* and ShMOLLI (Table 1).
In health, Hct then iron then HDL-cholesterol explain almost all (90%) of blood T1 variability with anaemia and low iron increasing T1 but with HDL reducing it.
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Rosmini, S., Bulluck, H., Treibel, T.A. et al. Hematocrit, iron and HDL-cholesterol explain 90% of variation in native blood T1. J Cardiovasc Magn Reson 18 (Suppl 1), O86 (2016). https://doi.org/10.1186/1532-429X-18-S1-O86