In a prospective IRB-approved study, 12 patients with a history of coronary artery disease (CAD) and chronic myocardial infarction (61 ± 9 years, 9 males) and 10 healthy subjects (52 ± 10 years, 8 males) were recruited to undergo CMR scans. All subjects were in sinus rhythm during CMR study. We assessed native T1 mapping using the slice interleaved T1 sequence in 5 short axis-slices (from apical to basal). The sequence was acquired in a free-breathing ECG-triggered slice-selective bSSFP. T1 mapping of each scan was estimated by voxel-wise curve fitting using a 2-paramter fit model. All images were corrected for in-plane motion between different T1 weighted scans. Native myocardial T1 in healthy subjects were measured over the three mid-ventricular slices by manually drawing epicardial and endocardial contours. The native T1 times of the remote myocardium of the CAD patients were measured by manually drawing a region of interest (ROI) on the three mid-ventricular slices and excluding the infarct area. An unpaired-samples T-test analysis was used to test for statistically significant differences between the two groups.