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- Open Access
Association between early diastolic dysfunction and increased peri-/epicardial fat: A CMR based study
© Dabir et al. 2016
- Published: 27 January 2016
- Cardiac Magnetic Resonance
- Diastolic Dysfunction
- Obese Subject
- Circumferential Strain
- Systolic Strain
Previous studies have shown that increased peri- and epicardial fat volume (PFV, EFV) leads to pathological diastolic strain (DS) and thus to cardiovascular morbidity. The aim of this study was to investigate the association between diastolic strain and EFV/PFV in obese and non-obese individuals without previous history of cardiovascular disease or additional cardiovascular risk factors.
Mean BMI in group A was 30.66 kg/m2 ± 5.71 and in group B 22.17 kg/m2 ± 1.76 (p < 0.05). Mean PFV and EFV were 238.61 ml ± 121.14 and 103.47 ml ± 37.05 in group A whereas mean PFV and EFV in group B accounted for 116.80 ml ± 43.14 and 60.71 ± 23.21 respectively (p < 0.05). Both groups revealed a peak circumferential systolic strain within a physiological range (group A:-23.60% ± 4.77; group B: -24.95% ± 3.52; p > 0.05). Group A (63.03 ± 11.83) showed significantly reduced mean early diastolic strain rates (EDSR) in comparison to group B (82.77 ± 16.33; p < 0.05). There were no significant differences between sex or age.
Obese subjects with increased peri-/epicardial fat volume had a significantly reduced EDSR in comparison to the non-obese control group.
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