Background
Patients receiving chronic transfusion develop iron overload in the liver, endocrine glands, and heart. Cardiac T2* has become the standard of care for detecting preclinical cardiac iron deposition and has been validated against tissue iron levels. Recent work suggests that T1 mapping can also be used to detect myocardial iron and may be more sensitive to early cardiac iron deposition. However, myocardial T1 measurements have not been as well standardized across pulse sequences, vendors, and field strengths. We compared two modified Look-Locker sequences (MOLLI and ShMOLLI) at 1.5 and 3 Tesla in patients with transfusional siderosis.