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Extracellular volume(ECV) quantified by T1 mapping could reflect effect of long term blood pressure control status in patients with essential hypertension
Journal of Cardiovascular Magnetic Resonance volume 18, Article number: P125 (2016)
Diffuse myocardial fibrosis is an important pathophysiological process involved into essential hypertension which may increase myocardium stiffness, cause ventricular remodeling and increase adverse cardiovascular risk eventually. It is strongly evident that optimal antihypertensive therapy will reduce the risk induced by hypertension, however, very few proportion of patients with hypertension can reach the recommended target of blood pressure (BP) control. So far little knowledge has been illuminated for effect of blood pressure control status on the myocardial fibrosis in hypertension. T1 mapping and extracellular volume (ECV) quantified by CMR has been adopted as a good method in examination of diffuse fibrosis. Besides, variation of serum fibrosis biomarkers may also reflect the degree of myocardial fibrosis. Based on the above we hypothesised that there was a correlation between ECV, serum fibrotic biomarkers and long-term BP control status in patients with essential hypertension.
T1 mapping by using modified Lock-Locker inversion recovery(MOLLI) sequence on a 3.0 Tesla scanner was performed on 40 hypertension patients (20 patients with documented well BP control and 20 with uncontrolled BP) and 20 healthy controls. Myocardial native, post T1 and average ECV of left ventricle were measured based on pre contrast and post contrast T1 mapping(15 minutes after intravenous injection with gadopentetate dimeglumine (0.15 mmol/kg). Serum PICP and ICTP level were detected with ELISA kits.
Uncontrolled hypertensive patients had a higher interventricular septum thickness(IVS) or left ventricular mass index(LVMI) than well controlled hypertensive patients, whereas there was no difference in left ventricular functional parameters between two groups. Hypertensive patients had higher mean ECV of left ventricular myocardium than normal controls, furthermore, mean ECV of LV in hypertensive patients with uncontrolled BP was higher than in patients with ECV well- controlled(29.4 ± 3.1 vs. 27.6 ± 2.1, p = 0.01),whereas the differences of native or post-contrast T1 time of LV myocardium between the two groups was not statistically significant (p = 0.75 and 0.19, respectively)(Table 1). By multi variants analysis, LVMI was independently correlated with ECV. PICP and the ratio of PICP/ICTP showed a trend towards higher in hypertension patients with uncontrolled BP than well-controlled (76.6 ± 13 ug/L vs. 66.82 ± 15.3 ug/L, p = 0.59 and 73.22 ± 13.6 vs. 66.82 ± 15.3, p = 0.96, respectively), and it was proved that there were correlations between increased ECV and elevated serum fibrosis biomarkers level (PICP: β = 0.37, p = 0.02, PICP/ICTP: β = 0.30, p = 0.03) (Table 2).
ECV of LV myocardium was higher in hypertensive patients which was associated with BP control status. ECV could be associated with the LV hypertrophy in patients with uncontrolled hypertension and could also reflect the changes of myocardial fibrosis in hypertension.
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Duan, X., Chen, Y. & Zhang, T. Extracellular volume(ECV) quantified by T1 mapping could reflect effect of long term blood pressure control status in patients with essential hypertension. J Cardiovasc Magn Reson 18 (Suppl 1), P125 (2016). https://doi.org/10.1186/1532-429X-18-S1-P125
- Myocardial Fibrosis
- Leave Ventricular Mass Index
- Gadopentetate Dimeglumine
- Uncontrolled Blood Pressure
- Diffuse Myocardial Fibrosis