- Poster presentation
- Open Access
Characterization of the myocardium in the 4-chamber view using accelerated free-breathing diffusion tensor MRI
© Mekkaoui et al. 2016
- Published: 27 January 2016
- Left Ventricle
- Fractional Anisotropy
- Mean Diffusivity
- Helix Angle
- Corrupted Image
Diffusion Tensor MRI (DTI) of the heart in vivo has conventionally been performed in the short-axis of the left ventricle (LV) . While this allows all three coronary territories to be seen, the short-axis acquisition orientation has some limitations. Full coverage of the LV in the short-axis requires roughly 12 to 15 slices, and accurate evaluation of the apex of the heart is often compromised. In addition, a nominal slice thickness of 8 mm is routinely used. An accelerated free-breathing DTI acquisition of the heart in its horizontal long-axis (4-chamber view) would require fewer slices (6), reduce acquisition time, and improve the characterization of the anterior and apical walls. A 4-chamber view, previously not performed, may be particularly useful when studying the remodeling of these regions.
DTI was performed in healthy volunteers (n = 7) on a clinical 3T scanner (Siemens Skyra), with an ECG-gated STE sequence. Acquisition parameters were: FOV = 360 × 200 mm2, resolution 2.5 × 2.5 mm2, thickness = 8 mm, in-plane GRAPPA rate 2, TE = 34 ms, b-values = 0 and 500 s/mm2, 10 diffusion-encoding directions, 8 averages, and 12 contiguous short-axis and 6 contiguous 4-chamber slices. Rate 2 SMS excitation was followed by a blipped-CAIPI readout. A sequential acquisition of diffusion-encoding directions evenly distributes the rejections across all directions ensuring that we can select enough samples of each direction. STR was applied to reduce the misregistration resulting from respiratory motion . Following STR, we utilize a novel entropy-based retrospective image selection method to reject corrupted images and maximize SNR. Mean diffusivity (MD), fractional anisotropy (FA) and helix angle (HA) values were compared between breath-hold and free-breathing.
Accelerated free-breathing DTI of the human heart can be accurately performed in the 4-chamber view. This capability may be valuable in characterizing remodeling in the anterior and apical walls. Imaging the myocardium in the 4-chamber view significantly reduces scan time compared to the conventional short-axis view, which could facilitate the clinical translation of cardiac DTI.
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