Volume 18 Supplement 1

19th Annual SCMR Scientific Sessions

Open Access

Longitudinal fiber dysfunction assessed during cine-cardiac magnetic resonance imaging is an independent predictor of adverse cardiac events

  • Satish J Chacko1,
  • Vibhav Rangarajan1,
  • Nikhil Jariwala1,
  • Simone Romano2,
  • Jaehoon Chung1 and
  • Afshin Farzaneh-Far1, 3
Journal of Cardiovascular Magnetic Resonance201618(Suppl 1):P135

https://doi.org/10.1186/1532-429X-18-S1-P135

Published: 27 January 2016

Background

Left ventricular systole involves coordinated contraction of longitudinal, circumferential, and radial myocardial fibers. Longitudinal fiber dysfunction appears to be an early marker for a number of pathological states. We hypothesized that reduced mitral annular plane systolic excursion (MAPSE) measured during cine-Cardiac Magnetic Resonance (CMR) imaging reflects changes in longitudinal fiber function and may be an early marker for adverse cardiovascular outcomes.

Methods

400 consecutive patients with known or suspected coronary artery disease undergoing CMR were prospectively enrolled. Lateral MAPSE was measured in the 4-chamber cine view by two independent observers. Patients were prospectively followed for major adverse cardiac events (MACE) - death, non-fatal myocardial infarction, hospitalization for heart failure or chest pain, and late revascularization. Cox proportional hazards regression modeling was used to identify factors independently associated with MACE.

Results

The mean age of the study population was 58(± 15) years, with a mean ejection fraction of 59(± 14%). 31% of the individuals had known coronary artery disease and 33% were diabetic. 72 MACE occurred during a median follow-up of 14.5 months. By Kaplan-Meier analysis, patients with lateral MAPSE ≤1.11 cm (median) experienced significantly higher incidence of MACE than patients with a MAPSE >1.11 cm (p = 0.0270) (Figure 1). After adjustment for established predictors (ejection fraction, age, sex, diabetes, hyperlipidemia, smoking, hypertension, late gadolinium enhancement) lateral MAPSE remained a significant independent predictor of MACE (HR = 2.43 per cm decrease; p = 0.037) (Figure 2).
Figure 1

Kaplan-Meier curves for MACE in patients with MAPSE above and below the median.

Figure 2

Univariable and multivariable predictors of MACE.

Conclusions

Longitudinal fiber dysfunction assessed with lateral MAPSE during cine-CMR is an independent predictor of MACE in patients with known or suspected coronary artery disease.

Authors’ Affiliations

(1)
Cardiology, University of Illinois at Chicago
(2)
Medicine, University of Verona
(3)
Cardiology, Duke University

Copyright

© Chacko et al. 2016

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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