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Volume 18 Supplement 1

19th Annual SCMR Scientific Sessions

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Application of Atlas-based global shape and local contraction analysis to single-ventricle congenital heart disease


Improvements in palliative surgery for infants born with single ventricle heart defects have increased their survival rate into adulthood, but the risk of developing heart failure remains high. The ventricles remodel to geometric extremes, making statistical comparison with the normal population difficult beyond the assessment of mass and volumes. We present a new method for evaluating cardiac geometry and systolic contraction variations in patients with single ventricle physiology with respect to the normal range of end-diastolic (ED) and end-systolic (ES) left ventricle (LV) shapes seen in the asymptomatic population.


Cardiac MRI of four single-ventricle patients with tricuspid atresia and > 10 years post-Fontan surgery were analyzed using custom software (CIM, Auckland, New Zealand). EDV (ml) = {183.5, 122.9, 123.6, 77.7}, ESV (ml) = {97.7, 60.9, 72.7, 35.3}, EF (%) = {46.8, 50.5, 41.2, 54.6}, and LVM (g) = {143.4, 116.8, 134.9, 63.3}. Each patient's LV shape was projected onto Principal Component Analysis (PCA) models previously derived from 1,991 asymptomatic volunteers [1], resulting as patient's principal scores for each PCA component. For local contraction analysis, thin-plate spline registration aligned LV shapes at ED onto the mean ED shape of the asymptomatic group. The corresponding ES shape was then deformed following the same ED shape alignment causing each patient LV to start the contraction from the same shape. ES points were compared statistically using the Mahalanobis distance.


Geometric LV shape extremes were identified at ED for P2 and P3 (Figure 1), even though LV volumes and masses were within normal ranges. Standardised principal scores of the four patients with respect to the asymptomatic group from the first five components are shown in Table 1. Individually, P4 had a small ventricular size, while P3 had a large inclination of the basal region affecting the LV outflow tract variation. P2 had a shorter height, a lower basal plane, and a thinner wall. For regional contraction, Figure 1 shows ES points after the ED alignment that lie outside the asymptomatic distributions. Each patient showed different patterns of local contraction abnormalities. P1 had abnormal lateral and septal epicardial wall contraction, while P3 shows abnormal contraction in multiple regions.

Table 1 Principal scores of four single-ventricle patients (P1-P4) after projecting onto PCA models of 1,991 asymptomatic subjects.
Figure 1
figure 1

LV shapes at ED from four single-ventricle patients. Spheres show ES points that lie outside the asymptomatic distributions (blue points are on endosurface, red points are on episurface). The bottom row shows view from the base with septum on the left side.


Atlas-based statistical shape analysis allows for identification of abnormal shape characteristics beyond mass and volume, as well as regional systolic contraction patterns. This may provide valuable new measures of disease progression and remodeling into heart failure relative to population norms.


  1. Medrano-Gracia P, et al: JCMR. 2014

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

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Suinesiaputra, A., Farrar, G.E., Gilbert, K. et al. Application of Atlas-based global shape and local contraction analysis to single-ventricle congenital heart disease. J Cardiovasc Magn Reson 18 (Suppl 1), P154 (2016).

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