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- Open Access
Segmental late gadolinium enhancement and gadolinium extracellular volume in hypertrophic cardiomyopathy
© Levine et al. 2016
- Published: 27 January 2016
- Cardiac Magnetic Resonance
- Late Gadolinium Enhancement
- Hypertrophic Cardiomyopathy
- Gadopentetate Dimeglumine
- Balance Steady State Free Precession
Late gadolinium enhancement (LGE) by cardiac magnetic resonance (CMR) is a common finding in patients with hypertrophic cardiomyopathy (HCM), and its extent correlates with clinical parameters such as ventricular tachycardia and sudden cardiac death. While LGE has been shown to reflect focal replacement fibrosis, recently optimized T1 mapping techniques have allowed for the quantification of extracellular volume (ECV), a measure of the diffuse interstitial fibrosis also observed in HCM. However, the relationship between LGE and ECV in HCM is not fully understood. The aim of this study was to evaluate the relationship between LGE and ECV in patients with HCM.
A retrospective chart review identified patients with a diagnosis of HCM referred for CMR at Northwestern Memorial Hospital between 1/1/2012 and 12/31/2014. Conventional segmented, inversion-recovery gradient recalled echo imaging was used to generate a stack of short axis images for LGE quantification using automated software (Medis). T1 mapping utilized pre- and 12-25 minutes post-contrast balanced steady state free precession (bSSFP) single-shot Modified Look-Locker inversion-recovery with data acquisition over 11 heartbeats. Three short axis slices (apical, mid-chamber, basal) were used to calculate ECV with hematocrit values from blood samples. Patients received 0.2 mmol/kg gadopentetate dimeglumine or 0.1 mmol/kg gadopentetate dimeglumine contrast at CMR. Segmental LGE and ECV values were calculated according to the AHA 16 segment model and compared. To characterize the presence of LGE in segments with varying degrees of ECV, patients were separated into LGE(+) and LGE(-) groups based on the presence of visually identifiable scar. All segments from LGE(+) patients were defined as LGE(+) and those from LGE(-) patients as LGE(-). All segments were pooled and grouped by range of ECV, and the total number of LGE(+) and LGE(-) segments for each ECV range was calculated.
The relationship between LGE and ECV in HCM varies by myocardial region, with mid-septal and antero-septal segments demonstrating the strongest correlations. Segments with greater ECV expansion demonstrated a significantly greater presence of LGE, but significant interstitial fibrosis can also occur in HCM patients with no visible scar. Further study is indicated for evaluating the significance and independent prognostic value of ECV in HCM.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.