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Volume 18 Supplement 1

19th Annual SCMR Scientific Sessions

Coronary flow reserve in adults with systemic right or single ventricles

Background

Late failure of systemic right and single ventricles is difficult to predict. Approximately 1/3 of subjects with congenitally corrected transposition of the great arteries (ccTGA) have congestive heart failure by the fifth decade and 2/3 of subjects with ccTGA and significant associated defects have congestive heart failure by the age of 45 years. Perfusion defects have been identified at rest in 55 % of subjects with systemic right ventricles by dipyridamole sestamibi and with exercise in 45 %, which are not due to endovascular obstructive coronary disease. Subjects with perfusion defects typically have worse right ventricular function, but not always. It may be tied to coronary flow reserve and coronary mismatch in these hypertrophied ventricles. The objective of this study was to assess the technical feasibility of stress perfusion imaging by CMR and calculate coronary flow reserve in adults with systemic right or single ventricles.

Methods

With IRB approval and informed consent, 14 adult patients with either a systemic right ventricle or a single ventricle underwent CMR with vasodilator stress perfusion imaging using adenosine (140 mcg/kg/min). Data collection included stress perfusion imaging, measurement of cardiac volume metrics and rest perfusion imaging at least 20 minutes after adenosine. Global myocardial blood flow (MBF) in ml/min/g and coronary flow reserve (CFR) were quantified using a fully quantitative model constrained deconvolution. Subjects underwent additional data collection, including lab work, 6-minute walk test and ECG.

Results

Table 1 summarizes patient characteristics and salient testing results. Two of 14 perfusion studies were not quanitifiable; one due to an incomplete first pass of contrast likely related to low EF, one had technical issues during imaging. Of the remaining 12 subjects, 10 had a measureable change in myocardial blood flow, and 2 did not. Stress measurements of myocardial blood flow were lower in most patients than established MBF values in normal ventricles. Figure 1 demonstrates the global myocardial blood flow at rest and during stress of a patient with high CFR.

Table 1 Characteristics and measured myocardial blood flow and coronary flow reserve of 12 included subjects.
Figure 1
figure1

Quantitative pixel maps showing myocardial blood flow values for a patient with D-TGA s/p Mustard at rest (left) and during adenosine stress (right).

Conclusions

Myocardial blood flow and coronary flow reserve are quantifiable with current techniques regardless of ventricular morphology. This technique shows promise as a potential method of risk stratification of this population.

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Correspondence to Laura Olivieri.

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Olivieri, L., Hsu, L., John, A. et al. Coronary flow reserve in adults with systemic right or single ventricles. J Cardiovasc Magn Reson 18, P173 (2016). https://doi.org/10.1186/1532-429X-18-S1-P173

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Keywords

  • Congestive Heart Failure
  • Dipyridamole
  • Myocardial Blood Flow
  • Perfusion Defect
  • Coronary Flow Reserve