- Poster presentation
- Open Access
Real-time inversion recovery for infarct visualization during MR-guided interventions
© Campbell-Washburn et al. 2016
- Published: 27 January 2016
- Late Gadolinium Enhancement
- Catheter Ablation
- Infarcted Tissue
- Late Gadolinium Enhancement Image
- Myocardial Biopsy
Real-time MR imaging is appealing for dynamic procedural guidance. Some MRI-guided procedures, such as catheter ablation or myocardial biopsy, may require the interventionist to visualize infarcted tissue in real-time in order to navigate devices relative to the lesion. Methods to interleave late gadolinium enhancement (LGE) images into a real-time imaging stream (1 in 5 frames) have been described previously for infarct visualization (1). Here, we implemented a real-time inversion recovery sequence to provide a stream of LGE images for procedural guidance, designed to rapidly toggle between high-frame rate "navigation mode" and lower-frame rate "infarct visualization mode".
Gadopenetate dimeglumine (Bayer Healthcare, Wayne, New Jersey) was administered intravenously (0.2 mmol/kg) to a swine model of myocardial infarction. Standard real-time imaging was used for "navigation mode" (bSSFP, TE/TR = 1.27/2.54 ms, flip angle = 45°, FOV = 300 mm, slice thickness = 6 mm, matrix = 192 x 144, GRAPPA factor = 2). In "infarct visualization mode", a non-selective inversion pre-pulse was performed before each real-time bSSFP acquisition. Inversion time (TI) was implemented as a real-time interactive parameter to enable optimal myocardial nulling, typical TI = 320 ms (approximately 25 minutes post-injection). The next inversion pulse immediately followed the image acquisition, with no additional time for signal recovery. A checkbox was used to switch between imaging modes on the fly.
This imaging method provides real-time stream of LGE images that can be used to navigate devices relative to infarcted tissue, with only a small penalty in frame-rate. This sequence was designed with added flexibility to toggle between high frame-rate imaging and lower frame rate infarct visualization. This method will be useful for MRI-guided procedures such as catheter ablation and myocardial biopsy.
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